Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934576
rs28934576
0.030 GeneticVariation BEFREE R273H expression in p53-null cancer cell SK-OV-3 and Saos-2 did not significantly affect cell invasion and migration activities. 17636407

2007

dbSNP: rs1049074086
rs1049074086
0.020 GeneticVariation BEFREE S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas. 21947242

2012

dbSNP: rs1284806277
rs1284806277
MOK
0.010 GeneticVariation BEFREE S100P promoted the invasion and metastasis of CRC by activating RAGE/ERK signaling and promoting the epithelial-mesenchymal transition (EMT). 26975699

2016

dbSNP: rs1058808
rs1058808
0.010 GeneticVariation BEFREE Ala1170Pro polymorphism in normal breast tissue was associated with age at diagnosis (p = 0.007), tumor size (p = 0.004) and lymphovascular invasion (p = 0.06). 27788409

2016

dbSNP: rs2227983
rs2227983
0.010 GeneticVariation BEFREE A marked decrease on EGFR phosphorylation (P < 0.01) and c-Myc activation (P = 0.02) was observed in patients with R497K polymorphism, which is associated with decreased invasion (P = 0.01), lower nodal involvement (P = 0.02), reduced subsequent metastasis (P < 0.01), and longer disease-free (P < 0.01) as well as overall (P < 0.01) survival in stage II/III colorectal carcinoma patients who had received curative surgery. 17575224

2007

dbSNP: rs1329032366
rs1329032366
0.010 GeneticVariation BEFREE A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. 18172305

2008

dbSNP: rs374733251
rs374733251
MET
0.010 GeneticVariation BEFREE A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. 18172305

2008

dbSNP: rs377444977
rs377444977
0.010 GeneticVariation BEFREE A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. 18172305

2008

dbSNP: rs78768932
rs78768932
PXN
0.010 GeneticVariation BEFREE A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. 18172305

2008

dbSNP: rs56391007
rs56391007
MET
0.010 GeneticVariation BEFREE A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials. 25605252

2015

dbSNP: rs121913529
rs121913529
0.020 GeneticVariation BEFREE Activation of ERK2, but not ERK1, also occurs only in K-Ras(G12D)-mutated PDECs cultured in three-dimensions and is a necessary intracellular signaling event for invasion based upon pharmacologic and short hairpin RNA (shRNA) inhibition. 22160930

2012

dbSNP: rs121913500
rs121913500
0.050 GeneticVariation BEFREE After transfection in vitro, IDH1-R132H overexpression led to reduced GSCs proliferation, migration and invasion, inducing apoptosis and improving GSC differentiation, accompanied by a significant reduction in activity of β-catenin. 29115585

2018

dbSNP: rs104894403
rs104894403
0.010 GeneticVariation BEFREE All three Cx26 variants also altered the distribution of filamentous actin and significantly reduced cell migration, while only the D66H mutant failed to inhibit cell invasion through matrigel. 16777986

2006

dbSNP: rs738791
rs738791
0.010 GeneticVariation BEFREE Although CT/TT genotype of MMP-11 gene rs738791 tended to increase the risk of developing stage II disease at least (p=0.035; OR: 2.16, 95% CI: 1.05-4.44) and deep stromal invasion more than 10 mm (p=0.043; OR: 2.08, 95% CI: 1.02-4.26) with CC as a reference in patients with uterine cervical cancer. 31337950

2019

dbSNP: rs201701502
rs201701502
0.010 GeneticVariation BEFREE Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model. 28676216

2017

dbSNP: rs895819
rs895819
0.010 GeneticVariation BEFREE Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene. 25399405

2014

dbSNP: rs11671784
rs11671784
0.010 GeneticVariation BEFREE Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene. 25399405

2014

dbSNP: rs587782359
rs587782359
0.010 GeneticVariation BEFREE Assessment of the P373L mutation effect was based on cell aggregation and invasion assays. 17434710

2007

dbSNP: rs2279744
rs2279744
0.010 GeneticVariation BEFREE Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population. 26289323

2015

dbSNP: rs1801270
rs1801270
0.010 GeneticVariation BEFREE Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population. 26289323

2015

dbSNP: rs1870377
rs1870377
KDR
0.010 GeneticVariation BEFREE At multivariate analysis, major vascular invasion and rs1870377 were independent factors in TTP and performance status, rs1870377, and rs2071559 were independent factors in OS. 25182707

2014

dbSNP: rs2071559
rs2071559
KDR
0.010 GeneticVariation BEFREE At multivariate analysis, major vascular invasion and rs1870377 were independent factors in TTP and performance status, rs1870377, and rs2071559 were independent factors in OS. 25182707

2014

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE At univariate analysis the worst outcome for PTC patients was significantly correlated with clinicopathological features (i.e. age, tumor size, extrathyroid extension, lymph node and distant metastases, advanced stage, vascular endothelial growth factor expression, and vascular invasion) and the BRAF(V600E) mutation (P < 0.002). 18682506

2008

dbSNP: rs121913377
rs121913377
0.100 GeneticVariation BEFREE At univariate analysis the worst outcome for PTC patients was significantly correlated with clinicopathological features (i.e. age, tumor size, extrathyroid extension, lymph node and distant metastases, advanced stage, vascular endothelial growth factor expression, and vascular invasion) and the BRAF(V600E) mutation (P < 0.002). 18682506

2008

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE BRAF (V600E) causes upregulation of tissue inhibitor of metalloproteinase-1 (TIMP-1), which promotes cell invasion in papillary thyroid carcinoma (PTC). 23893334

2013