rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
R273H expression in p53-null cancer cell SK-OV-3 and Saos-2 did not significantly affect cell invasion and migration activities.
|
17636407 |
2007 |
rs1049074086
|
|
|
0.020 |
GeneticVariation |
BEFREE |
S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
|
21947242 |
2012 |
rs1284806277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
S100P promoted the invasion and metastasis of CRC by activating RAGE/ERK signaling and promoting the epithelial-mesenchymal transition (EMT).
|
26975699 |
2016 |
rs1058808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Ala1170Pro polymorphism in normal breast tissue was associated with age at diagnosis (p = 0.007), tumor size (p = 0.004) and lymphovascular invasion (p = 0.06).
|
27788409 |
2016 |
rs2227983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A marked decrease on EGFR phosphorylation (P < 0.01) and c-Myc activation (P = 0.02) was observed in patients with R497K polymorphism, which is associated with decreased invasion (P = 0.01), lower nodal involvement (P = 0.02), reduced subsequent metastasis (P < 0.01), and longer disease-free (P < 0.01) as well as overall (P < 0.01) survival in stage II/III colorectal carcinoma patients who had received curative surgery.
|
17575224 |
2007 |
rs1329032366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion.
|
18172305 |
2008 |
rs374733251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion.
|
18172305 |
2008 |
rs377444977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion.
|
18172305 |
2008 |
rs78768932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion.
|
18172305 |
2008 |
rs56391007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials.
|
25605252 |
2015 |
rs121913529
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Activation of ERK2, but not ERK1, also occurs only in K-Ras(G12D)-mutated PDECs cultured in three-dimensions and is a necessary intracellular signaling event for invasion based upon pharmacologic and short hairpin RNA (shRNA) inhibition.
|
22160930 |
2012 |
rs121913500
|
|
|
0.050 |
GeneticVariation |
BEFREE |
After transfection in vitro, IDH1-R132H overexpression led to reduced GSCs proliferation, migration and invasion, inducing apoptosis and improving GSC differentiation, accompanied by a significant reduction in activity of β-catenin.
|
29115585 |
2018 |
rs104894403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All three Cx26 variants also altered the distribution of filamentous actin and significantly reduced cell migration, while only the D66H mutant failed to inhibit cell invasion through matrigel.
|
16777986 |
2006 |
rs738791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although CT/TT genotype of MMP-11 gene rs738791 tended to increase the risk of developing stage II disease at least (p=0.035; OR: 2.16, 95% CI: 1.05-4.44) and deep stromal invasion more than 10 mm (p=0.043; OR: 2.08, 95% CI: 1.02-4.26) with CC as a reference in patients with uterine cervical cancer.
|
31337950 |
2019 |
rs201701502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model.
|
28676216 |
2017 |
rs895819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |
rs11671784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |
rs587782359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessment of the P373L mutation effect was based on cell aggregation and invasion assays.
|
17434710 |
2007 |
rs2279744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.
|
26289323 |
2015 |
rs1801270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.
|
26289323 |
2015 |
rs1870377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At multivariate analysis, major vascular invasion and rs1870377 were independent factors in TTP and performance status, rs1870377, and rs2071559 were independent factors in OS.
|
25182707 |
2014 |
rs2071559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At multivariate analysis, major vascular invasion and rs1870377 were independent factors in TTP and performance status, rs1870377, and rs2071559 were independent factors in OS.
|
25182707 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
At univariate analysis the worst outcome for PTC patients was significantly correlated with clinicopathological features (i.e. age, tumor size, extrathyroid extension, lymph node and distant metastases, advanced stage, vascular endothelial growth factor expression, and vascular invasion) and the BRAF(V600E) mutation (P < 0.002).
|
18682506 |
2008 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
At univariate analysis the worst outcome for PTC patients was significantly correlated with clinicopathological features (i.e. age, tumor size, extrathyroid extension, lymph node and distant metastases, advanced stage, vascular endothelial growth factor expression, and vascular invasion) and the BRAF(V600E) mutation (P < 0.002).
|
18682506 |
2008 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF (V600E) causes upregulation of tissue inhibitor of metalloproteinase-1 (TIMP-1), which promotes cell invasion in papillary thyroid carcinoma (PTC).
|
23893334 |
2013 |