|
rs751295137
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
|
rs760101437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
|
rs751295137
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Using esophageal epithelial cells transformed by the overexpression of EGFR and p53(R175H), we find novel evidence of a functional link between p53(R175H) and the c-Met receptor tyrosine kinase to mediate tumor cell invasion.
|
23792586 |
2013 |
|
rs760101437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Using esophageal epithelial cells transformed by the overexpression of EGFR and p53(R175H), we find novel evidence of a functional link between p53(R175H) and the c-Met receptor tyrosine kinase to mediate tumor cell invasion.
|
23792586 |
2013 |
|
rs751295137
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
|
rs760101437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
|
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
|
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
|
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, LncRNA BC087858 could promote cells invasion and induce non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT via up- regulating ZEB1 and Snail in NSCLC.
|
27409677 |
2016 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also indicated that Inhibition of CXCR4 with small interfering RNA, neutralizing antibody, or receptor antagonist significantly suppressed the EGFR-L858R-dependent cell invasion.
|
26338423 |
2015 |
|
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also indicated that Inhibition of CXCR4 with small interfering RNA, neutralizing antibody, or receptor antagonist significantly suppressed the EGFR-L858R-dependent cell invasion.
|
26338423 |
2015 |
|
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also indicated that Inhibition of CXCR4 with small interfering RNA, neutralizing antibody, or receptor antagonist significantly suppressed the EGFR-L858R-dependent cell invasion.
|
26338423 |
2015 |
|
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrary, the lack of effect of gefitinib on EGFR phosphorylation in the H1975 cells (EGFR-T790M) correlated with the absence of effects on cell migration and invasion.
|
24167634 |
2013 |
|
rs121913430
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Matrigel invasion assays showed enhanced invasion with G735S, G796S and E804G mutants.
|
18193092 |
2008 |
|
rs377444977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion.
|
18172305 |
2008 |
|
rs2227983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A marked decrease on EGFR phosphorylation (P < 0.01) and c-Myc activation (P = 0.02) was observed in patients with R497K polymorphism, which is associated with decreased invasion (P = 0.01), lower nodal involvement (P = 0.02), reduced subsequent metastasis (P < 0.01), and longer disease-free (P < 0.01) as well as overall (P < 0.01) survival in stage II/III colorectal carcinoma patients who had received curative surgery.
|
17575224 |
2007 |