|
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Using the SKBR3 breast cancer and p53-null H1299 lung cancer cells stably expressing the R175H p53 mutant protein, we demonstrated that GON triggers the appearance of a wild-type-like p53 protein by using conformation-specific antibodies, immunoprecipitation, DNA-binding assays and target gene expression. p53 restoration was associated with a G2/M arrest, senescence, reduced cell migration, invasion and increased cell death.
|
30010803 |
2018 |
|
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
|
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Using esophageal epithelial cells transformed by the overexpression of EGFR and p53(R175H), we find novel evidence of a functional link between p53(R175H) and the c-Met receptor tyrosine kinase to mediate tumor cell invasion.
|
23792586 |
2013 |
|
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
|
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we demonstrate that the hotspot mutation, p53-R273H, promotes cell migration, invasion in vitro and tumor metastasis in vivo. p53-R273H significantly represses expression of DLX2, a homeobox protein involved in cell proliferation and pattern formation.
|
28796261 |
2017 |
|
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, ATF3 appeared to suppress R175H- and R273H-mediated cancer cell migration and invasion as a consequence of preventing the transcription factor p63 from inactivation by mutp53.
|
24554706 |
2014 |
|
rs28934576
|
|
|
0.030 |
GeneticVariation |
BEFREE |
R273H expression in p53-null cancer cell SK-OV-3 and Saos-2 did not significantly affect cell invasion and migration activities.
|
17636407 |
2007 |
|
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that 21 of 34 tumors with high-grade TB had KRAS mutations (P=.001) and KRAS G12D and PIK3CA exon 9 variants were significantly associated with high-grade TB (P=.002 and .006, respectively); furthermore, tumors with KRAS mutations in exons 3 and 4 tended to have lymphovascular tumor emboli and perineural invasion (P=.044 and .049, respectively).
|
28188750 |
2017 |
|
rs11540652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IOWA-1T harbors a homozygous R248Q mutation of the TP53 gene; in vitro invasion assay was comparable to BT-549 and greater than MCF-7.
|
25326397 |
2015 |
|
rs1064793929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The calcium-binding protein S100P is expressed in a variety of human cancer cells and is important in cancer cell growth and invasion.
|
23785431 |
2013 |
|
rs587778720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the DN effect on tumor migration and invasion, we generated cells that stably co-expressed wild-type (wt) and R273H DN mutant TP53 (273H cells), and wt and R213Q recessive mutant TP53 (213Q cells), by transfection in endometrial cancer cells HHUA that expressed wt p53.
|
17636407 |
2007 |