rs121913459
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0.020 |
GeneticVariation |
BEFREE |
Using BCR-ABL-expressing myelogenous and lymphoid cell lines and mouse models of CML and B-cell acute lymphoblastic leukemia (B-ALL) induced by wild-type BCR-ABL or T315I mutant-BCR-ABL, we evaluated the inhibitory effects of omacetaxine on CML and B-ALL.
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19322212 |
2009 |
rs121434592
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0.010 |
GeneticVariation |
BEFREE |
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
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20440266 |
2010 |
rs780634396
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0.010 |
GeneticVariation |
BEFREE |
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
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20440266 |
2010 |
rs1057519721
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|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we identify G935R, Y931C, and E864K mutations within the JAK2 kinase domain that confer resistance across a panel of JAK inhibitors, whether present in cis with JAK2 V617F (observed in MPNs) or JAK2 R683G (observed in B-ALL).
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22271575 |
2012 |
rs529311209
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|
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0.010 |
GeneticVariation |
BEFREE |
In this study, we identify G935R, Y931C, and E864K mutations within the JAK2 kinase domain that confer resistance across a panel of JAK inhibitors, whether present in cis with JAK2 V617F (observed in MPNs) or JAK2 R683G (observed in B-ALL).
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22271575 |
2012 |
rs77375493
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|
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0.010 |
GeneticVariation |
BEFREE |
In this study, we identify G935R, Y931C, and E864K mutations within the JAK2 kinase domain that confer resistance across a panel of JAK inhibitors, whether present in cis with JAK2 V617F (observed in MPNs) or JAK2 R683G (observed in B-ALL).
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22271575 |
2012 |
rs1057519723
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0.010 |
GeneticVariation |
BEFREE |
This study provides clues in understanding the mechanism of JAK2 R683S (G) mutations caused B-ALL.
|
23748007 |
2013 |
rs1800629
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|
0.010 |
GeneticVariation |
BEFREE |
The presence of at least one A allele in TNF-α SNP rs1800629 should suggest a closer monitoring in B-cell acute lymphoblastic leukemia standard risk patients.
|
24798719 |
2014 |
rs156697
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|
|
0.010 |
GeneticVariation |
BEFREE |
This study found no significant association between Pre-B ALL and GSTO1 A140D and GSTO2 N142D polymorphisms.
|
25726706 |
2015 |
rs4925
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0.010 |
GeneticVariation |
BEFREE |
This study found no significant association between Pre-B ALL and GSTO1 A140D and GSTO2 N142D polymorphisms.
|
25726706 |
2015 |
rs866838052
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|
|
0.010 |
GeneticVariation |
BEFREE |
This study found no significant association between Pre-B ALL and GSTO1 A140D and GSTO2 N142D polymorphisms.
|
25726706 |
2015 |
rs4958351
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|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with GRIA1 rs4958351 AA/AG genotype showed significantly reduced risk to ASP hypersensitivity compared to patients with GG genotype in the T-cell ALL subgroup (OR = 0.05 (0.01-0.26); p = 4.70E-04), while no such association was found in pre-B-cell ALL.
|
26457809 |
2015 |
rs62527607
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|
0.010 |
GeneticVariation |
BEFREE |
The prevalence of the T-allele of rs62527607 [GT] SNP in childhood T-ALL and pre-B-ALL was 28.3% and 11.2%, respectively.
|
27372260 |
2017 |
rs1057519743
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|
0.010 |
GeneticVariation |
BEFREE |
The prevalence of CRLF2 overexpression, CRLF2-P2RY8 fusion, CRLF2 F232C mutation, and JAK2 and IL7R mutational status were analyzed, and the prognostic impact of CRLF2 overexpression and P2RY8-CRLF2 on B-ALL was evaluated by assessing their influence on overall survival and event-free survival.
|
27637012 |
2017 |
rs13107325
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0.010 |
GeneticVariation |
BEFREE |
The variant, rs13107325, is almost exclusive of European populations and is one of the most pleiotropic variants of the genome, being associated at genome-wide significant level with several additional traits, such as body mass index, Crohn's disease, blood pressure related-traits, and serum levels of manganese, N-terminal pro-B-type natriuretic peptide and HDL-cholesterol.
|
28557351 |
2018 |
rs1346944271
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0.010 |
GeneticVariation |
BEFREE |
Furthermore, we show that primary ALL mononuclear cells harboring the JAK2 R938Q mutation display reduced sensitivity to the JAK1/2 ATP-competitive inhibitor ruxolitinib in vitro, compared to ALL cells that carry a more common JAK2 pseudokinase domain mutation.
|
29025600 |
2017 |
rs11980379
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|
0.010 |
GeneticVariation |
BEFREE |
The previously reported pediatric B-ALL GWAS variant, rs11980379 (<i>IKZF1</i>), replicated in B-ALL pediatric patients (OR<sub>meta</sub> = 2.3; 95% CI, 1.5, 3.7; <i>P</i><sub>meta</sub> = 1.0 × 10<sup>-9</sup>), with evidence of heterogeneity (<i>P</i> = .02) between males and females.
|
29296818 |
2017 |
rs189434316
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|
|
0.010 |
GeneticVariation |
BEFREE |
We identified 1 novel variant, rs189434316, significantly associated with odds of normal cytogenetic B-ALL (odds ratio from meta-analysis [OR<sub>meta</sub>] = 3.7; 95% confidence interval [CI], 2.5, 6.2; <i>P</i> value from meta-analysis [<i>P</i><sub>meta</sub>] = 6.0 × 10<sup>-9</sup>).
|
29296818 |
2017 |
rs2393732
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|
0.010 |
GeneticVariation |
BEFREE |
The seven SNPs were associated with risk of pre-B ALL in younger children; however, rs2393732, rs2393782, rs2893881, and rs4948488 were not associated with susceptibility in older children and adolescents.
|
31227872 |
2019 |
rs4948488
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|
|
0.010 |
GeneticVariation |
BEFREE |
The seven SNPs were associated with risk of pre-B ALL in younger children; however, rs2393732, rs2393782, rs2893881, and rs4948488 were not associated with susceptibility in older children and adolescents.
|
31227872 |
2019 |
rs121913459
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|
|
0.020 |
GeneticVariation |
BEFREE |
Purinostat mesylate efficiently attenuated Ph<sup>+</sup> B-ALL progression and significantly prolonged the survival both in BL-2 secondary transplantation model with clinical patient symptoms of Ph<sup>+</sup> B-ALL, <i>BCR-ABL(T315I)</i>-induced primary B-ALL mouse model, and PDX model derived from patients with relapsed Ph<sup>+</sup> B-ALL post TKI treatment.
|
31439580 |
2019 |
rs12430881
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|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, a strong risk of B-cell acute lymphoblastic leukemia was associated with rs35958982 and rs12430881 polymorphisms.
|
31565544 |
2019 |
rs35958982
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|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, a strong risk of B-cell acute lymphoblastic leukemia was associated with rs35958982 and rs12430881 polymorphisms.
|
31565544 |
2019 |
rs3780135
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|
|
0.010 |
GeneticVariation |
BEFREE |
At locus 9p13.2 (rs3780135, <i>PAX5</i>), the risk allele frequency was significantly higher in B-ALL subjects than ancestral allele frequency (OR = 2.17, CI [1.37-3.43], <i>P</i> = 0.000).
|
31565544 |
2019 |