|
rs874945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
HOTAIR SNP rs920778, rs7958904 and rs8749</span>45 are susceptible to cancer risk.
|
27965458 |
2017 |
|
rs874945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant.
|
29497311 |
2018 |
|
rs874945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, there is no significant association between SNPs variants and cancer risk under any five genetic models for rs4759314, rs1899663 and rs874945.
|
30941992 |
2019 |
|
rs874945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, no significant association was found between the rs1899663, rs874945, and rs4759314 polymorphisms and susceptibility of cancer.
|
29463216 |
2018 |
|
rs874945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, no significant association was identified between the rs874945, rs4759314 and rs1899663 polymorphisms and cancer susceptibility.
|
27791260 |
2017 |
|
rs12826786
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not.
|
29497311 |
2018 |
|
rs12826786
|
|
|
0.030 |
GeneticVariation |
BEFREE |
For the rs12826786 polymorphism, we identified it significantly increased susceptibility to cancer risk in all genetic models rather than heterozygous models.
|
29463216 |
2018 |
|
rs12826786
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor types.
|
28083786 |
2017 |
|
rs2046210
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In The Cancer Genome Atlas samples, the AA/AG risk genotypes of SNP rs2046210 were associated with a significantly higher expression level of the AKAP12 gene and a lower level of the ESR1 gene in tumor tissue.
|
26645718 |
2016 |
|
rs2046210
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer.
|
23535825 |
2013 |
|
rs2069514
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial.
|
25472037 |
2015 |
|
rs2069514
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed that no significant associations with the risk of cancer were found in any model (allele contrast, codominant, dominant, or recessive model) in terms of rs2069514 and rs3569413 when all studies were pooled into a meta-analysis.
|
23462460 |
2013 |
|
rs1015213
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate if the single nucleotide polymorphisms rs3753841, rs1015213 and rs11024102, recently implicated in the development of acute primary angle closure or primary angle closure glaucoma, are associated with ocular biometric characteristics of British adults in the European Prospective Investigation of Cancer-Norfolk eye study.
|
23505305 |
2013 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data demonstrated the CCL2-2518A/G (rs1024611) polymorphism is significantly associated with risk of gynecological cancer, and the association differs by ethnicity.
|
29458367 |
2018 |
|
rs10896449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As part of the Cancer Genetic Markers of Susceptibility (CGEMS) Initiative, the region flanking the most significant marker, rs10896449, was fine mapped in 10 272 cases and 9123 controls of European origin (10 studies) using 120 common single nucleotide polymorphisms (SNPs) selected by a two-staged tagging strategy using HapMap SNPs.
|
21531787 |
2011 |
|
rs132793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs13293512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis showed that rs13293512 CC genotype was associated with an increased risk of BC in patients with negative estrogen receptor (adjusted OR = 2.39; 95% CI: 1.32-4.30; <i>P=</i>0.004), patients with negative progesterone receptor (adjusted OR = 1.92; 95% CI: 1.11-3.33; <i>P=</i>0.02), patients with T1-2 stage cancer (adjusted OR = 1.77; 95% CI: 1.07-2.93; <i>P=</i>0.03), and patients with N1-3 stage cancer (adjusted OR = 1.89; 95% CI: 1.13-3.17; <i>P=</i>0.015).
|
31028134 |
2019 |
|
rs143969848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 5.4% of suspected Lynch syndrome patients have a rare single-nucleotide variant (G > A; rs143969848; 2.5% in gnomAD European, non-Finnish) within a highly conserved CTCF-binding motif, which disrupts enhancer activity in SW620 colorectal carcinoma cells.<b>Conclusions:</b> A CTCF-bound region within the <i>MLH1</i>-35 enhancer regulates <i>MLH1</i> expression in colorectal cells and is worthy of scrutiny in future genetic screening strategies for suspected Lynch syndrome associated with loss of MLH1 expression.<i>Clin Cancer Res; 24(18); 4602-11.©2018 AACR</i>.
|
29898989 |
2018 |
|
rs16892766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility.
|
25293934 |
2015 |
|
rs17432750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action.
|
25529635 |
2015 |
|
rs2057768
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After a comprehensive analysis, no significant evidence was revealed for the association between four IL-4R polymorphisms (rs1801275, rs1805010, rs1805015, rs2057768) and cancer susceptibility in the overall population, as well as the subgroup analysis stratified by ethnicity, cancer type, the genotyping method or the source of control.
|
31031864 |
2019 |
|
rs2145048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provided the first evidence that SFRS3 rs2145048 was associated with breast cancer susceptibility in Chinese women, which might represent a biomarker to improve the identification of individuals at high risk of this malignancy.
|
31078657 |
2019 |
|
rs2410373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In analysis of selected candidate cancer susceptibility genes, two MSR1 SNPs (rs9325782, GEE p = 0.008 and rs2410373, FBAT p = 0.021) were associated with prostate cancer and three ERBB4 SNPs (rs905883 GEE p = 0.0002, rs7564590 GEE p = 0.003, rs7558615 GEE p = 0.0078) were associated with breast cancer.
|
17903305 |
2007 |
|
rs2555639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For one additional SNP, rs2555639, the T allele showed increased cancer risk and decreased 15-PGDH expression, but just missed statistical significance (p-adjusted = 0.063).
|
23717544 |
2013 |
|
rs2660753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study.
|
21415361 |
2011 |