|
rs144779807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Introduction of EGFR mutations E746-A750 del and L858R progressed HBECs toward malignancy as measured by soft agar growth, including EGF-independent growth, but failed to induce tumor formation.
|
16489012 |
2006 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15.33 locus are significantly associated with cancer risk as reported in genome-wide association studies (GWAS), but there are no reported studies for squamous cell carcinoma of the head and neck (SCCHN).
|
20802237 |
2010 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In all genetic models, the association between the TERT rs2736100 polymorphism and cancer risk was significant.
|
22221621 |
2012 |
|
rs2853676
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mean RTL at age 60 was associated with four genetic variants of the hTERT gene (rs2736100, rs2853672, rs2853677, and rs2853676), two of which reported to be associated with cancer risk.
|
22539396 |
2012 |
|
rs2853677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mean RTL at age 60 was associated with four genetic variants of the hTERT gene (rs2736100, rs2853672, rs2853677, and rs2853676), two of which reported to be associated with cancer risk.
|
22539396 |
2012 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The rs2736100 association demonstrates an influence of variation at 5p15.33 on CRC risk and further evidence that the 5p15.33 (TERT-CLPTM1L) locus has pleiotropic effects (reflecting generic or lineage-specific effects) on cancer risk.
|
22878375 |
2012 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
|
22994782 |
2012 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis did not show that the TERT rs2736098 plays an important role in cancer risk.
|
23244087 |
2012 |
|
rs10069690
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The cancer risk alleles of rs2242652 and rs1006</span>9690, respectively, increase silencing and generate a truncated TERT splice variant.
|
23535731 |
2013 |
|
rs2242652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.
|
23535731 |
2013 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
|
23707794 |
2013 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Increased cancer risk was found between TERT-rs2736100, as well as CLPTM1L-rs402710 and cancer susceptibility.
|
23707794 |
2013 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant differences (Bonferroni corrected p-valuecor ≤ 0.0197) in the frequency of alleles distribution between all cancer and control subjects were observed for four (rs2736098, rs13281615, rs1219648, rs2981582) out of 16 SNPs.
|
24171766 |
2013 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the meta-analysis, a borderline significant association between the rs2736098 polymorphism and overall cancer risk was observed (AA vs. GG: OR = 1.25, 95% CI = 1.07-1.46; AA vs. AG+GG: OR = 1.22, 95% CI = 1.06-1.41; additive model: OR = 1.10, 95% CI = 1.02-1.18), and further stratifications demonstrated a moderately increased risk for lung and bladder cancer, Asian ethnicity and hospital-based studies.
|
24260099 |
2013 |
|
rs2853669
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed an association of allele rs2853669 C with increased risk of prostate cancer (co-dominant model TC vs. TT OR = 1.65, P = 0.002; additive model OR = 1.42, P = 0.005; dominant model: OR = 1.64, P = 0.001) and allele rs7726159 A with reduced risk of this malignancy (сo-dominant model: AA vs. CC OR = 0.42, P = 0.002; additive model: OR = 0.69, P = 0.002; dominant model: OR = 0.67, P = 0.01; recessive model: OR = 0.48, P = 0.005).
|
25296732 |
2015 |
|
rs7726159
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed an association of allele rs2853669 C with increased risk of prostate cancer (co-dominant model TC vs. TT OR = 1.65, P = 0.002; additive model OR = 1.42, P = 0.005; dominant model: OR = 1.64, P = 0.001) and allele rs7726159 A with reduced risk of this malignancy (сo-dominant model: AA vs. CC OR = 0.42, P = 0.002; additive model: OR = 0.69, P = 0.002; dominant model: OR = 0.67, P = 0.01; recessive model: OR = 0.48, P = 0.005).
|
25296732 |
2015 |
|
rs2735940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.
|
25716168 |
2015 |
|
rs2853676
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant association between TERT rs2853676 allele A and cancer susceptibility was demonstrated under a per-allele risk analysis (OR = 1.08, 95% CI = 1.04-1.13).
|
26042809 |
2015 |
|
rs2853669
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A common single-nucleotide polymorphism in the telomerase reverse transcriptase (TERT) promoter, rs2853669 influences patient survival rates and the risk of developing cancer.
|
26575952 |
2016 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We genotyped telomerase reverse transcriptase (TERT) rs2736100 variants, the SNP associated with a risk of multiple-types of cancer, in patients with UTUC (n = 212) and evaluated the relationship between the rs2736100 and UTUC risk by comparing to 289 healthy controls.
|
26934125 |
2016 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
|
27273963 |
2016 |
|
rs7726159
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In logistic regression models, the per-allele odds ratio (OR) for cancer was 1.05 (95% CI 1.03-1.07) for the allele sum, 1.05 (1.02-1.09) for rs7726159, 1.05 (1.02-1.08) for rs1317082 and 1.07 (1.02-1.12) for rs2487999.
|
27498151 |
2016 |
|
rs2736098
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are significantly associated with cancer susceptibility.
|
28416747 |
2017 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
For rs2736100, the cancer risk genotype CC was significantly associated with a reduced incidence of TERT promoter mutations compared to AA + AC variants [Odds ratio (OR): 0.181, 95% Confidence interval (CI): 0.0543-0.601, P = 0.004].
|
28416747 |
2017 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The TERT rs2736100 polymorphism was associated with increased overall cancer risk in five genetic models [homozygous model (GG vs. TT): odds ratio (OR) = 1.39, 95% confidence interval (95% CI) = 1.26-1.54, P < 0.001; heterozygous model (TG vs. TT): OR = 1.16, 95% CI = 1.11-1.23, P < 0.001; dominant model (TG + GG vs. TT): OR = 1.23, 95% CI = 1.15-1.31, P < 0.001; recessive model (GG vs. TG + TT): OR = 1.25, 95% CI = 1.16-1.35, P < 0.001; and allele contrast model (G vs. T): OR = 1.17, 95% CI = 1.12-1.23, P < 0.001].
|
28418878 |
2017 |