rs1799782
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0.100 |
GeneticVariation |
BEFREE |
Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer.
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12496039 |
2002 |
rs1799782
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0.100 |
GeneticVariation |
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
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12618003 |
2003 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
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12618003 |
2003 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
Growing evidence suggests that the polymorphism of DNA base excision repair gene XRCC1 Arg399Gln is associated with altered DNA repair proficiency and subsequent cancer susceptibility; however, no evidence is available for malignant lymphoma.
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15104288 |
2004 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
In this study, we have shown that three nsSNPs, which were predicted to have functional consequences (XRCC1-R399Q, XRCC3-T241M, XRCC1-R280H), were already found to be associated with cancer risk.
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15159313 |
2004 |
rs1799782
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0.100 |
GeneticVariation |
BEFREE |
The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.
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16030121 |
2005 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.
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16030121 |
2005 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied.
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16038584 |
2005 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
There was no association between cancer risk and the APE1/APEX1 Asp148Glu and XRCC1 Arg280His polymorphisms.
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16221808 |
2005 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
For Arg(399)Gln (10 studies, 3729 cases, 3927 controls), the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR 0.95, 95% CI 0.82 to 1.10; P = 0.48).
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18336890 |
2008 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
For Arg399Gln, the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR = 0.92, 95% CI, 0.71-1.19; P = 0.51).
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19034980 |
2008 |
rs1799782
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0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms in XRCC1, Arg194Trp and Arg399Gln, have been repeatedly associated with risk for and outcome of numerous types of cancer treated with radio- and chemotherapy.
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20044627 |
2009 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms in XRCC1, Arg194Trp and Arg399Gln, have been repeatedly associated with risk for and outcome of numerous types of cancer treated with radio- and chemotherapy.
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20044627 |
2009 |
rs1799782
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0.100 |
GeneticVariation |
BEFREE |
The results showed that the 194Trp/Trp homozygote had a 31% increased risk of cancer than </span>194T</span>rp/Arg and 194Arg/Arg genotypes, OR was 1.31 and 95%CI was 1.13 to 1.53.
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21499756 |
2011 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
Further, XRCC1 Arg280His variant though dormant individually, may also contribute to the development of cancer in combination with XPD Arg751Gln.
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21945240 |
2012 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
These findings indicated that XRCC1 Arg280His polymorphism may play a role in cancer development.
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22975644 |
2012 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
For example, there was a positive association between the OGG1 Ser326Cys variant and gastric and lung cancer, while the XRCC1 Arg399Gln variant was associated with reduced cancer risk.
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23023028 |
2012 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of the DNA repair gene X-ray repair cross-complementing protein 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln have been shown to alter the DNA repair activity and to be associated with genetic susceptibility to several types of cancer.
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23425027 |
2013 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of the DNA repair gene X-ray repair cross-complementing protein 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln have been shown to alter the DNA repair activity and to be associated with genetic susceptibility to several types of cancer.
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23425027 |
2013 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
Moreover, our work also points out the importance of new studies for Arg399Gln association in some cancer types, such as glioma, gastric cancer, and oral cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg399Gln polymorphism in cancer development.
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24205095 |
2013 |
rs1799782
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0.100 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
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24497981 |
2014 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
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24497981 |
2014 |
rs25489
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0.100 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
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24497981 |
2014 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
These results also indicated that a joint effect between PARP-1 Val762Ala and XRCC1 Arg399Gln could be involved in the risk of cancer development (OR = 3.53, 95% CI = 1.30-9.59).
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24853559 |
2014 |
rs25487
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0.100 |
GeneticVariation |
BEFREE |
Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.
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24922697 |
2014 |