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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk.
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31759353 |
2019 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
TP53 Arg72Pro (rs1042522 C > G) and miR-34b/c rs4938723 (T > C) polymorphisms have been known to modify cancer susceptibility.
|
31325764 |
2019 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms' tumor.
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28260929 |
2017 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the p53 R72P polymorphism.
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28594296 |
2017 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
Risk of cancer</span> specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered.
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28336930 |
2017 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
Hence, this study explores the single and combined effects of cancer risk, age of onset and cancer type of three single nucleotide polymorphisms (SNPs)-TP53 Pro72Arg, MDM2 SNP285 and SNP309-already described as modifiers on TP53 mutation carriers but not properly investigated in LFS Suggestive patients.
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26956143 |
2016 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis.
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26619844 |
2016 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis.
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26320432 |
2015 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting.
|
25768405 |
2015 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on thyroid cancer risk.
|
25835179 |
2015 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
Mouse models for the p53 R72P polymorphism have recently been developed but a role for this SNP in modifying cancer risk in response to viral and chemical carcinogens has yet to be established experimentally.
|
23475592 |
2014 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
We have also found that the ectopic expression of p53-R248W/P72R in MG63 cells promoted cancer stem-like features, as high proliferation rate, sphere formation, clonogenic growth, high migration and invasive ability; furthermore, it strongly increased the levels of stemness proteins.
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24373920 |
2014 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy.
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25605158 |
2014 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg).
|
24935583 |
2014 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
TP53 P72R polymorphism significantly contributes to increased African American cancer disparity.
|
24743655 |
2014 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
TP53 Arg72Pro polymorphism has been proposed to have some effects on host's susceptibility to cancer.
|
24375191 |
2014 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR.
|
23053979 |
2012 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism.
|
21976716 |
2012 |
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rs1131691014
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0.100 |
GeneticVariation |
BEFREE |
Thus, it is evident from our study that Arg72Pro SNP is implicated in kangri cancer and that the rare, proline-related allele is connected with higher susceptibility to kangri cancer.
|
22249977 |
2012 |
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rs1131691014
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|
0.100 |
GeneticVariation |
BEFREE |
Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity.
|
22116280 |
2011 |
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rs1131691014
|
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0.100 |
GeneticVariation |
BEFREE |
Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility.
|
20886596 |
2011 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated.
|
21468597 |
2011 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the TP53 gene Arg72Pro polymorphism appreciably influence on occurrence of chromosome aberrations in cancer.
|
20512840 |
2010 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on bladder cancer risk.
|
21156242 |
2010 |
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rs1131691014
|
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|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown that functional polymorphisms at the MDM2 SNP309 T/G and p53 Arg72Pro may be associated with cancer susceptibility.
|
18575717 |
2008 |