|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the APC I1307K variant is a reliable marker for overall cancer risk (OR 2.53).
|
26421687 |
2016 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An APC mutation (I1307K) was found in an index case of a non-Jewish woman and her son with attenuated familial adenomatous polyposis (A-FAP) and no family history of cancer.
|
22180177 |
2012 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is currently only sporadic clinical genetic testing offered for this variant, as neither the exact increase in cancer risk and therefore the appropriate screening strategies for I1307K carriers, nor the acceptability of such testing in Jewish communities have been determined.
|
16195945 |
2005 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
|
16228836 |
2005 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The risk of developing any cancer in carriers of the I1307K mutation of the adenopolyposis coli (APC) gene is significantly increased (odds ratio 1.5, P = 0.01).
|
12856637 |
2003 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that early age at diagnosis and family history of cancer cannot be used to predict who is likely to harbour the I1307K APC germline mutation carriers.
|
11720476 |
2001 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation of the adenopolyposis coli gene (APC), located on chromosome 5q21-q22, is associated with an increased risk of cancer in Ashkenazi Jews.
|
11106824 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The high prevalence of the I1307K allele among BRCA1/2 carriers is not associated with increased cancer risk but seems to be genetically connected because of Jewish ancestry.
|
10901363 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed sex, age, family history, personal history, and gene test results of patients at increased risk for cancer who sought cancer risk counseling at the Johns Hopkins (JH) CRC Risk Assessment Clinic (n = 91), and those submitting samples to the JH Pathology Molecular Diagnostic Laboratory (n = 256) for APC I1307K testing.
|
10756345 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K mutation represents a novel paradigm for cancer-predisposing genes, as it is associated with moderately increased risk of neoplasia without other associated distinguishing phenotypic features.JAMA.2000;284:857-860
|
10938175 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are at least nine major cancer susceptibility syndromes that infer an increased risk for colorectal cancer and/or colorectal polyposis; hereditary nonpolyposis colorectal cancer syndrome, Muir-Torre syndrome, Turcot syndrome, the I1307K polymorphism of the APC gene, familial adenomatous polyposis, attenuated familial adenomatous polyposis, Peutz Jeghers syndrome, juvenile polyposis, and the PTEN hamartoma tumor syndrome.
|
11005140 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews.
|
9869603 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
|
9973276 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, in this family, there appears to be no relationship between the I1307K polymorphism and the presence or absence of cancer.
|
9831355 |
1998 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the Ashkenazi Jewish population, the I1307K allele is unlikely to increase the risk of ovarian cancer or of cancer in general.
|
9679945 |
1998 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the role of I1307K in cancer, we genotyped 5,081 Ashkenazi volunteers in a community survey.
|
9731533 |
1998 |