The results indicated that TP53 rs78378222 was significantly associated with an increased risk of overall canc</span>er (AC vs. AA: OR = 1.511, 95% CI = 1.285-1.777).
Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings.