Gene: HIF1A ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
0.050 GeneticVariation BEFREE These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility. 31762805

2019
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
0.050 GeneticVariation BEFREE Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk. 24293391

2014
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
0.050 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations. 25117331

2014
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
0.050 GeneticVariation BEFREE This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer. 24063654

2013
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
0.050 GeneticVariation BEFREE The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer. 15538748

2005
dbSNP: rs11549467
rs11549467
HIF1A ; HIF1A-AS3
0.030 GeneticVariation BEFREE Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk. 24293391

2014
dbSNP: rs11549467
rs11549467
HIF1A ; HIF1A-AS3
0.030 GeneticVariation BEFREE When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC). 24824937

2014
dbSNP: rs11549467
rs11549467
HIF1A ; HIF1A-AS3
0.030 GeneticVariation BEFREE Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89). 23042446

2012
dbSNP: rs2057482
rs2057482
HIF1A ; HIF1A-AS2 ; HIF1A-AS3
0.020 GeneticVariation BEFREE The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies. 31744467

2019
dbSNP: rs2057482
rs2057482
HIF1A ; HIF1A-AS2 ; HIF1A-AS3
0.020 GeneticVariation BEFREE Overall, C1772T and G1790A but not rs2057482 were associated with increased risk for cancer. 24046090

2014