Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Design and synthesis of diphenylpyrimidine derivatives (DPPYs) as potential dual EGFR T790M and FAK inhibitors against a diverse range of cancer cell lines. 31706682

2020

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Following drug resistance in patients with lung cancer treated by EGFR TKIs, a biopsy is required to obtain sufficient cancer tissue for T790M detection in order to select potential beneficiaries suitable for third-generation EGFR TKIs, such as osimertinib. 31407509

2019

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE We reviewed all patients with T790M-positive NSCLC and acquired resistance to initial EGFR-TKIs who were administered osimertinib between March 2016 and January 2018 at the Tokyo Metropolitan Cancer and Infectious Diseases Center in Komagome Hospital, Japan. 31372272

2019

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Non-Small Cell Lung Cancer with Resistance to EGFR-TKI Therapy: CT Characteristics of T790M Mutation-positive Cancer. 30015588

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE This approach detects mutations as subtle as the drug-resistance-conferring cancer mutation EGFR T790M (a single C → T substitution) with an estimated specificity of 99.99999%, surpassing even the leading PCR-based methods and enabling detection of 1 mutant molecule in a background of at least 1 million wild-type molecules. 30125495

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE To assess the biological implications of <i>RET</i> fusions in an <i>EGFR</i>-mutant cancer, we expressed CCDC6-RET in PC9 (<i>EGFR</i> del19) and MGH134 (<i>EGFR</i> L858R/T790M) cells and found that CCDC6-RET was sufficient to confer resistance to EGFR tyrosine kinase inhibitors (TKI). 30257958

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib. 29183267

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE T790M mutations disappeared from cancer cells in the pleural effusion after a break from the treatment drug and cytotoxic agent administration. 30145590

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE This could further help avoid unnecessary tumor biopsies for T790M mutation testing.<i>Clin Cancer Res; 24(12); 2944-50.©2018 AACR</i>. 29535126

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Liquid biopsy offers a potential alternative to tissue biopsy for detection of genetic alterations in cancer, and it has been introduced into clinical practice to detect the tyrosine kinase inhibitor (TKI) resistance-conferring T790M mutation of epidermal growth factor receptor (EGFR) in patients with non-small-cell lung cancer (NSCLC). 30289575

2018

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE These conjugates exhibited high antiproliferative potency against a number of cancer cell lines, including the epidermal growth factor receptor (EGFR) L858R/T790M mutant cell. 28236592

2017

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Indeed, the use of plasma testing to screen for epidermal growth factor receptor (<i>EGFR</i>) T790M mutant positive non-small cell lung cancer (NSCLC) patients eligible for treatment with third-generation EGFR inhibitors was recently approved by the U.S. Food and Drug Administration and is incorporated into the most recent version of the National Comprehensive Cancer Center guidelines as an alternative to tissue biopsy. 29184671

2017

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE In two patients, the ctDNA dynamics suggested the presence of cancer cell populations only with the T790M mutation. 26678713

2016

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE The objective responses were observed in NSCLC patients with EGFR T790M mutation.Mol Cancer Ther; 15(11); 2586-97.©2016 AACR. 27573423

2016

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE The molecular beacon-based approach enabled rapid and sensitive detection of the EGFR mutation (T790M) in NSCLC with in situ fluorescence imaging, which can be directed to determine various treatment options in patients with cancer. 20805561

2010

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE While they produce dramatic responses in a subset of patients-primarily those with activating EGFR mutations-remissions are typically limited to several months due to acquired drug resistance, frequently associated with the secondary T790M mutation in EGFR.In this issue of Cancer Cell, Li et al. report that an irreversible EGFR kinase inhibitor, HKI-272, had limited activity in a mouse lung cancer model driven by an EGFR mutant harboring T790M and an activating mutation. 17613432

2007

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE Reverse Phase Proteomic Array (RPPA, MD Anderson Cell Lines Project), RNAseq (Cancer Cell Line Encyclopedia) and vemurafenib sensitivity (Cancer Therapeutic Response Portal) data for BRAF-V600E cancer cell lines were curated. 31672130

2019

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE Patients with this cancer have a high frequency (~50%) of oncogenic <i>BRAF</i> mutations, particularly BRAF V600E. 29387237

2018

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE In FNA biopsy samples (n=186), immunocytochemical expression of caveolin-1 and BRAF V600E mutation coincided with malignancy. 27818286

2017

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE We found that gene mutations for EGFR (P = .02) and ALK (P < .001) were associated with cancer diagnosis at a younger age, and a similar trend existed for ERBB2 (P = .15) and ROS1 (P = .10) but not BRAF V600E (P = .43). 26720421

2016

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE The usefulness of immunohistochemistry (IHC) as a new approach for the detection of BRAF V600E in cancer patients has been recently reported. 23927882

2013

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE The BRAF inhibitor vemurafenib has become an important treatment option for melanoma patients, the majority of whom have a BRAF(V600E) mutation driving their malignancy. 23074264

2012

dbSNP: rs397517132
rs397517132
0.070 GeneticVariation BEFREE The aim of the correlative tumour tissue studies was to investigate the relationship between EGFR gene copy numbers, activation of the EGFR pathway, expression and mutation of E-cadherin, V600E BRAF mutation and clinical outcome of patients with gastric and OGJ cancer treated with cetuximab combined with FUFOX. 22152101

2011

dbSNP: rs1057519861
rs1057519861
0.030 GeneticVariation BEFREE Noteworthy effect of slight variation in aliphatic chain length of trisubstituted imidazole inhibitors against epidermal growth factor receptor L858R/T790M/C797S mutant in cancer therapy. 30582282

2019

dbSNP: rs1057519861
rs1057519861
0.030 GeneticVariation BEFREE We also demonstrated that PE2988 cells, a C797S-independent osimertinib-resistant primary cancer cell line from a lung cancer patient, responded to combined AXL inhibitor and osimertinib treatment. 31162839

2019