Gene: AKT1 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2494752
rs2494752
AKT1
0.030 GeneticVariation BEFREE Furthermore, it was demonstrated that AKT1 rs2494752 GG and C polymorphism was more aggressive than other AKT1 rs2494752 cancer cells. 30127980

2018
dbSNP: rs121434592
rs121434592
AKT1
0.030 GeneticVariation BEFREE Conclusion This study provides the first clinical data that AKT1 E17K is a therapeutic target in human cancer. 28489509

2017
dbSNP: rs2494752
rs2494752
AKT1
0.030 GeneticVariation BEFREE Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk. 28423632

2017
dbSNP: rs2494752
rs2494752
AKT1
0.030 GeneticVariation BEFREE In addition, AG genotype and GG/AG genotype of rs2494752 was associated with increased risk of cancer. 29259266

2017
dbSNP: rs121434592
rs121434592
AKT1
0.030 GeneticVariation BEFREE Recently, a somatic activating mutation in the AKT1 gene (E17K) was identified in several cancer types. 19853286

2010
dbSNP: rs121434592
rs121434592
AKT1
0.030 GeneticVariation BEFREE We analysed the presence of the AKT1 E17K mutation in 731 cancer tissues by a single-strand conformation polymorphism assay. 18392055

2008
dbSNP: rs2498794
rs2498794
AKT1
0.010 GeneticVariation BEFREE These data suggest that the rs2498794 polymorphism of the AKT1 gene is associated with a long smoking duration and may be involved in the predisposition to cancer when the smoking duration is short or the cigarettes per day is rate low. 26137473

2015