rs9933638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analyses displayed that lung cancer risk of individuals with rs9933638(GG+GA) were 1.89 times higher than that of rs9933638AA carriers (OR = 1.893, 95% CI = 1.308-2.741, P = 0.001).
|
27486757 |
2016 |
rs9915936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of seven studied polymorphic sites showed a strong protective effect in subjects having mutant genotype for Axin2 148 C >T and heterozygous genotype for 1365 G > A and 1712 + 19 G > T towards lung cancer risk.
|
28378643 |
2017 |
rs9912300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model.
|
25227797 |
2014 |
rs9895829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
African Americans with Pro-T-A-G-G haplotypes of the combined TP53 polymorphisms TP53_01 (rs1042522), TP53_65 (rs9895829), TP53_66 (rs2909430), TP53_16 (rs1625895), and TP53_11 (rs12951053) had both an increased risk for lung cancer (odds ratio, 2.32; 95% confidence interval, 1.18-4.57) and a worsened lung cancer prognosis (hazards ratio, 2.38; 95% confidence interval, 1.38-4.10) compared with those with Arg-T-A-G-T haplotypes.
|
17301252 |
2007 |
rs969129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, AGAA haplotype (rs10213865, rs969129, rs118137916 and rs10053847) increased LC risk (OR =1.30, <i>P</i>=0.041).
|
31354347 |
2019 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A functional variant at 19q13.3, rs967591G>A, is associated with shorter survival of early-stage lung cancer.
|
23775331 |
2013 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Join effect of three SNPs (PPP1R13L rs1970764, CD3EAP rs967591, GLTSCR1 rs1035938) on chromosome 19q13.3 showed that the designated haplotype8 (rs 1970764<sup>G</sup>-rs967591<sup>A</sup>-rs1035938<sup>C</sup>) [OR (95% CI)=1.60(1.11-2.32), P/0.012] andhaplotype8 (rs1970764<sup>G</sup>-rs967591<sup>G</sup>-rs1035938<sup>T</sup>) [OR (95% CI)=2.45 (1.17-5.12), P=0.018] were associated with increased risk of lung cancer (adjusted by smoking duration).
|
30128886 |
2018 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The common haplotype containing PPP1R13L rs1970764(G), CD3EAP rs967591(A), and CD3EAP rs735482(C) was associated with lung cancer [adjusted OR (95 % CI) = 1.29 (1.03-1.62), P = 0.028].
|
26563375 |
2016 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, this study suggests that CD3EAP rs967</span>591 variant allele carriers are at increased susceptibility of lung cancer among nonsmoking Chinese women.
|
23624123 |
2013 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, we found that variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer, but the high-risk diplotype predefined among Caucasians was rare and the diplotype is unlikely to confer lung cancer risk in a Chinese population.
|
22335888 |
2012 |
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MDR (multifactor dimensionality reduction) analyses showed that smoking history as main effect and three-way models (smoking duration, 19p13.3-GADD45B rs3783501, 19q13.3-CD3EAP rs967591) (P = 0.001-0.002) indicated statistically significant association with lung cancer risk.
|
28870783 |
2017 |
rs9651118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
|
23372658 |
2013 |
rs9554314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant association was observed for the other two SNPs (rs664393 and rs9554314) and either COPD or lung cancer risk.
|
24891316 |
2014 |
rs9535826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients.
|
24852429 |
2014 |
rs9469031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three low-frequency missense variants in BAT2 (rs9469031, c.1544C>T [p.Pro515Leu]; odds ratio [OR] = 0.55, p = 1.28 × 10(-10)), FKBPL (rs200847762, c.410C>T [p.Pro137Leu]; OR = 0.25, p = 9.79 × 10(-12)), and BPIFB1 (rs6141383, c.850G>A [p.Val284Met]; OR = 1.72, p = 1.79 × 10(-7)); these variants were associated with lung cancer risk. rs9469031 in BAT2 and rs6141383 in BPIFB1 were also associated with the age of onset of lung cancer (p = 0.001 and 0.006, respectively).
|
25937444 |
2015 |
rs941759532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OGG1 S326C homozygote was suggested to be associated with lung cancer risk in Caucasians (homozygote OR, 1.34; 95% CI, 1.01-1.79) based on 2,569 cases and 4,178 controls from 4 studies but not in Asians.
|
18990748 |
2008 |
rs9387478
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicates that the rs9387478 genotype was associated with overall survival in nonsmoking female patients with lung cancer, although it was not significant after adjusting for multiple testing.
|
26689248 |
2016 |
rs938682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
rs937283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study showed that rs937283 was significantly associated with the risk of LC, and the factors of age, gender, smoking status and drinking status would affect such association.
|
29777315 |
2018 |
rs9350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this hospital-based study, the association of Exol A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with lung cancer risk in a central Taiwanese population was investigated.
|
19331228 |
2009 |
rs9346917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A further comprehensive validation of 114 informative single nucleotide polymorphism (SNP) variants of PARK2, in 2,484 cases and controls with well-defined lung cancer and COPD phenotypes, found rs577876, rs6455728 and rs9346917 (p<0.01) to be significantly associated with lung cancer development in people with COPD.
|
27329585 |
2016 |
rs9344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings support the conclusion that cell cycle regulation may play a role in lung cancer development and that CCND1 rs9344 polymorphism together with smoking habit maybe a useful biomarker for lung cancer prediction.
|
21965784 |
2011 |
rs9324921
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression revealed that four variants in NR3C1 and SATB1 were significantly associated with lung cancer risk after false discovery rate (FDR) correction [For NR3C1, rs9324921: odds ratio (OR)=1.23, P for FDR=0.029; rs12521436: OR=0.85, P for FDR=0.040; rs4912913: OR=1.17, P for FDR=0.040; For SATB1, rs6808523: OR=1.33, P for FDR=0.040].
|
27179949 |
2016 |
rs931794
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from our current case-control study and meta-analysis offered insight of association between rs931794 and lung cancer risk, suggesting the variant of rs931794 might be related with increased lung cancer risk.
|
26079375 |
2015 |
rs931794
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The goal of this study was to determine whether recently identified genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on chromosome 15q25.1 contributes to risk of lung cancer in African Americans.
|
19641473 |
2009 |