Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9261204
rs9261204
0.010 GeneticVariation BEFREE G allele of SNP rs9261204 was significantly associated with an increased risk of lung cancer when compared with A allele (OR: 1.45; 95% CI: 1.19-1.75; P = 1.06 × 10-4). 27166266

2016

dbSNP: rs3757328
rs3757328
0.010 GeneticVariation BEFREE SNP rs3757328 was also associated with increased risk of lung cancer (OR: 1.34; 95% CI: 1.07-1.67; P = 0.011). 27166266

2016

dbSNP: rs17723637
rs17723637
0.010 GeneticVariation BEFREE Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. 29059373

2018

dbSNP: rs760943842
rs760943842
0.010 GeneticVariation BEFREE Loss of TP53-DNA interaction induced by p.C135R in lung cancer. 17914575

2007

dbSNP: rs1327135247
rs1327135247
0.010 GeneticVariation BEFREE The functional germline variant c.353T>C (p.Val118Ala) of Snai1 confers consistently decreased risks of lung cancer and COPD, and this variant affects lung cancer risk through a mediation effect of COPD. 24354880

2014

dbSNP: rs1487151044
rs1487151044
0.010 GeneticVariation BEFREE The functional germline variant c.353T>C (p.Val118Ala) of Snai1 confers consistently decreased risks of lung cancer and COPD, and this variant affects lung cancer risk through a mediation effect of COPD. 24354880

2014

dbSNP: rs3747093
rs3747093
0.010 GeneticVariation BEFREE We found a significant association between rs3747093 located in the CCDC116 promoter and lung cancer risk (OR = 0.91, P <sub>meta</sub> = 7.81 × 10<sup>-6</sup>). 28653172

2017

dbSNP: rs2131877
rs2131877
0.010 GeneticVariation BEFREE In the meta-analysis, rs2131877 at the chromosome 3q29 region was the most significant biomarker of lung cancer susceptibility in Koreans (P = 2.43 × 10(-8)). 20876614

2010

dbSNP: rs2025811
rs2025811
0.010 GeneticVariation BEFREE We further showed that Xrn2 promotes proliferation and inhibits squamous differentiation in human lung epithelial cells and polymorphisms in human homolog XRN2 are associated with human lung cancer (rs2025811, P=1.90 x 10(-3), OR=1.20). 19915612

2010

dbSNP: rs132770
rs132770
0.010 GeneticVariation BEFREE In this hospital-based case-control study, the association of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter G-31A (rs132770), and intron 3 (rs132774) polymorphisms with lung cancer risk in a Taiwanese population, was studied. 22399625

2012

dbSNP: rs2267437
rs2267437
0.010 GeneticVariation BEFREE In this hospital-based case-control study, the association of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter G-31A (rs132770), and intron 3 (rs132774) polymorphisms with lung cancer risk in a Taiwanese population, was studied. 22399625

2012

dbSNP: rs5751129
rs5751129
0.010 GeneticVariation BEFREE In this hospital-based case-control study, the association of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter G-31A (rs132770), and intron 3 (rs132774) polymorphisms with lung cancer risk in a Taiwanese population, was studied. 22399625

2012

dbSNP: rs132774
rs132774
0.010 GeneticVariation BEFREE In this hospital-based case-control study, the association of XRCC6 promoter T-991C (rs5751129), promoter G-57C (rs2267437), promoter G-31A (rs132770), and intron 3 (rs132774) polymorphisms with lung cancer risk in a Taiwanese population, was studied. 22399625

2012

dbSNP: rs2075685
rs2075685
0.020 GeneticVariation BEFREE In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. 19729825

2009

dbSNP: rs2075685
rs2075685
0.020 GeneticVariation BEFREE It appeared that rs2075685, although associated with increased expression of a reporter gene and lung cancer risk in the Texas populations, did not have an effect on lung cancer risk in other populations. 21296624

2011

dbSNP: rs6869366
rs6869366
0.020 GeneticVariation BEFREE In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. 19729825

2009

dbSNP: rs6869366
rs6869366
0.020 GeneticVariation BEFREE In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis. 23321468

2013

dbSNP: rs2075686
rs2075686
0.010 GeneticVariation BEFREE As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. 19729825

2009

dbSNP: rs7727691
rs7727691
0.010 GeneticVariation BEFREE As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. 19729825

2009

dbSNP: rs28360071
rs28360071
0.020 GeneticVariation BEFREE In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. 19729825

2009

dbSNP: rs28360071
rs28360071
0.020 GeneticVariation BEFREE In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis. 23321468

2013

dbSNP: rs10040363
rs10040363
0.010 GeneticVariation BEFREE In the replication study of rs10040363, rs1478486, rs9293329, and rs2075685, however, only rs10040363 achieved a borderline association with a decreased risk of lung cancer in a dominant model (adjusted OR=0.80, 95% CI=0.62-1.03 and P=0.079). 21296624

2011

dbSNP: rs1805377
rs1805377
0.010 GeneticVariation BEFREE In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis. 23321468

2013

dbSNP: rs28360317
rs28360317
0.010 GeneticVariation BEFREE As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. 19729825

2009

dbSNP: rs3734091
rs3734091
0.010 GeneticVariation BEFREE As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. 19729825

2009