Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2352028
rs2352028
0.010 GeneticVariation BEFREE 44 top candidate SNPs were identified that might alter the risk of lung cancer in never smokers. rs2352028 at chromosome 13q31.3 was subsequently replicated with an additive genetic model in the four independent studies, with a combined odds ratio of 1.46 (95% CI 1.26-1.70, p=5.94x10(-6)). 20304703

2010

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE Lung cancer harboring epidermal growth factor receptor (EGFR) mutations and treated with EGFR tyrosine kinase inhibitors (TKIs) all eventually develop acquired resistance to the treatment, with half of the patients developing EGFR T790M resistance mutations. 28620690

2018

dbSNP: rs121434568
rs121434568
0.100 GeneticVariation BEFREE L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer. 16890322

2007

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE Arg399Gln is a SNP with some functional evidence and has been shown previously to be an important SNP associated with lung cancer, mostly for Asians. 19029194

2009

dbSNP: rs369410616
rs369410616
0.010 GeneticVariation BEFREE Arg399Gln is a SNP with some functional evidence and has been shown previously to be an important SNP associated with lung cancer, mostly for Asians. 19029194

2009

dbSNP: rs727504256
rs727504256
0.010 GeneticVariation BEFREE E709K and Ins770G as well as L858R appear to be functional mutations based on the use of Ba/F3 cells. 19726454

2009

dbSNP: rs146795390
rs146795390
0.030 GeneticVariation BEFREE V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors. 25057940

2015

dbSNP: rs775057330
rs775057330
0.010 GeneticVariation BEFREE A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. 16410263

2006

dbSNP: rs7969931
rs7969931
0.010 GeneticVariation BEFREE A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. 16410263

2006

dbSNP: rs3743078
rs3743078
0.010 GeneticVariation BEFREE A case-control study of 529 cases and 567 controls was performed to study the association of three SNPs (rs3743076, rs3743078, and rs3743073) in CHRNA3 with lung cancer risk in Chinese Han population using logistic regression models. 20234319

2010

dbSNP: rs1130409
rs1130409
0.060 GeneticVariation BEFREE A common APE1 polymorphism, a T-->G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an association that was modified by cigarette smoking. 16425270

2006

dbSNP: rs146795390
rs146795390
0.030 GeneticVariation BEFREE A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable? 23380224

2013

dbSNP: rs11637635
rs11637635
0.010 GeneticVariation BEFREE A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). 20587604

2010

dbSNP: rs17408276
rs17408276
0.010 GeneticVariation BEFREE A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). 20587604

2010

dbSNP: rs16969968
rs16969968
0.100 GeneticVariation BEFREE A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). 20587604

2010

dbSNP: rs578776
rs578776
0.030 GeneticVariation BEFREE A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). 20587604

2010

dbSNP: rs1042028
rs1042028
0.020 GeneticVariation BEFREE A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. 14688021

2004

dbSNP: rs9282861
rs9282861
0.020 GeneticVariation BEFREE A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. 14688021

2004

dbSNP: rs967591
rs967591
0.030 GeneticVariation BEFREE A functional variant at 19q13.3, rs967591G>A, is associated with shorter survival of early-stage lung cancer. 23775331

2014

dbSNP: rs78768932
rs78768932
PXN
0.030 GeneticVariation BEFREE A murine in vivo xenograft model of the most common paxillin mutation (A127T) showed increased cell proliferation and invasive tumour growth, establishing an important role for paxillin in the development of lung cancer. 21045234

2011

dbSNP: rs868188
rs868188
0.010 GeneticVariation BEFREE A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. 16691626

2006

dbSNP: rs121434568
rs121434568
0.100 GeneticVariation BEFREE A patient with metastatic lung adenocarcinoma harboring concurrent EGFR L858R, EGFR germline T790M, and PIK3CA mutations: the challenge of interpreting results of comprehensive mutational testing in lung cancer. 24453288

2014

dbSNP: rs121434569
rs121434569
0.100 GeneticVariation BEFREE A patient with metastatic lung adenocarcinoma harboring concurrent EGFR L858R, EGFR germline T790M, and PIK3CA mutations: the challenge of interpreting results of comprehensive mutational testing in lung cancer. 24453288

2014

dbSNP: rs4646903
rs4646903
0.020 GeneticVariation BEFREE A pertinent combination of multiple "at-risk" genotypes of CYP1A1 rs4646903, the GSTM1 deletion polymorphism and ERCC2 rs13181 was at a 5.94-fold (95% CI = 2.77-12.7) increased risk of lung cancer. 22525558

2012

dbSNP: rs13181
rs13181
0.100 GeneticVariation BEFREE A pertinent combination of multiple "at-risk" genotypes of CYP1A1 rs4646903, the GSTM1 deletion polymorphism and ERCC2 rs13181 was at a 5.94-fold (95% CI = 2.77-12.7) increased risk of lung cancer. 22525558

2012