rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For Arg48Gly, individuals with 48GG genotype had a significantly increased risk of lung cancer compared with individuals with 48CC (OR 3.859; 95% CI 2.536-5.87).
|
21674184 |
2012 |
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
rs1002481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate association between REV3L polymorphisms and lung cancer risk in a Chinese population, we first genotyped 15 common polymorphisms of the REV3L gene and found that three single nucleotide polymorphisms (rs465646, rs459809 and rs1002481) were significantly associated with lung cancer risk.
|
22349819 |
2013 |
rs10036653
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional analyses of ATG10 rs10036653 polymorphism suggested that ATG10 A allele might increase transcription factor OCT4 binding affinity compared to the T allele in lung cancer cells.
|
29259263 |
2017 |
rs10040363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the replication study of rs10040363, rs1478486, rs9293329, and rs2075685, however, only rs10040363 achieved a borderline association with a decreased risk of lung cancer in a dominant model (adjusted OR=0.80, 95% CI=0.62-1.03 and P=0.079).
|
21296624 |
2011 |
rs10053847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IL-7R</i> rs10053847 was correlated with a decreased LC risk, while <i>IL-7R</i> rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation.
|
31354347 |
2019 |
rs10054203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms exhibited prominent associations with lung cancer risk, including rs7726159 (OR = 1.34, 95%CI: 1.18-1.52, P = 7.78 × 10<sup>-6</sup> ), rs10054203 (OR = 1.29, 95%CI: 1.13-1.46, P = 1.37 × 10<sup>-4</sup> ), rs2736107 (OR = 1.28, 95%CI: 1.11-1.47, P = 5.14 × 10<sup>-4</sup> ), and rs2853677 (OR = 1.23, 95%CI: 1.08-1.39, P = 0.002).
|
30680798 |
2019 |
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
rs10079250
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that TP63 rs7631358 G > A and CSF1R rs10079250 A > G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.
|
28449811 |
2017 |
rs10079250
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the three SNPs, particularly CSF1R rs10079250, may contribute to lung cancer susceptibility in never-smoking females.
|
25144241 |
2014 |
rs10079250
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] rs13009079T>C) were found to be significantly associated with lung cancer in the same direction as the discovery set.
|
25144241 |
2014 |
rs1014264982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The non-conservative substitution of HMG20b residue Ala247 with Pro, reported in human lung cancer, disrupts these activities of HMG20b, impairing cytokinesis in a trans-dominant manner.
|
25486196 |
2014 |
rs10187911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For external validation, nineteen SNPs were replicated in another sample set composed of 293 cases and 495 controls, and only rs10187911 on 2p16.3 was significantly associated with lung cancer development (dominant model, OR of TG or GG, 1.58, P = 0.025).
|
23772147 |
2013 |
rs1019340046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show: (1) wild-type p53 stimulates the transcription of reporter genes with p53CON and RGC in their 5' region while most p53 mutants occurring in human cancers have lost this activity; (2) the R273H mutant retains transcriptional activity for the p53CON sequence but not RGC; (3) some mutants are temperature-sensitive for the transcriptional activity with the p53CON but not the RGC sequence; (4) p53 mutants vary in their ability to inhibit wild-type p53 transactivation but there is no difference between p53CON and RGC sequences; (5) lung cancer cells with endogenous mutant p53 proteins (M246I in H23 cells and R248L in H322 cells) retain transcriptional activity for the p53CON but not the RGC sequence.
|
8336941 |
1993 |
rs10213865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IL-7R</i> rs10053847 was correlated with a decreased LC risk, while <i>IL-7R</i> rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation.
|
31354347 |
2019 |
rs10244817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratified by genotype, there was a suggestion of a dose-response relationship between tertiles of telomere length and risk of lung cancer among the POT1 rs10244817 common variant carriers (OR (95% CI)=1.33 (0.47-3.75), 3.30 (1.14-9.56), respectively) but not among variant genotype carriers (p(interaction)=0.05).
|
19285750 |
2009 |
rs10254120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further demonstrate that P53 V157D and/or PMS2 R20Q mutant promotes lung cancer cell proliferation.
|
23981578 |
2014 |
rs1026411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-<i>PCAT1</i> (rs1026411 G>A, rs12543663 A>C, rs710886 T>C, and rs16901904 T>C) to investigate the association between genetic variant in lncRNA-<i>PCAT1</i> and susceptibility to lung cancer.
|
31464517 |
2019 |
rs1035938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests that haplotypes consisting of PPP1R13L rs1970764-CD3EAP rs961591-GLTSCR1 rs1035938 on Chr19q13.3, interaction of smoking and GLTSCR1 rs1035938-ATM rs11212592, and synergistic action of PPP1R13L rs1970764 and ATM rs11212592 may associate with lung cancer risk in the Chinese population.
|
30128886 |
2018 |
rs10412613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stratified analyses, the association of PPP2R1A:rs10412613 and lung cancer risk appeared stronger among population of younger age at diagnosis and never smokers.
|
28383694 |
2017 |
rs1041983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
But increased risk of lung cancer was found in association with NAT2 C282T polymorphism (TT vs. CC + TC: OR = 1.58, 95% CI = 1.11-2.25).Our meta-analysis demonstrates that TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility.
|
26656326 |
2015 |
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Statistical analyses of histological types of lung cancer in comparison with the control individuals indicated a significant difference between SULT1A1 Arg(213)His polymorphism and SCC (p = 0.027) and other types of cancer (p = 0.037), except SMCC (p = 0.854).
|
19350537 |
2009 |
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is not associated with lung cancer risk in Asians and Caucasians, but possible elevation for genotype (GA/AA) in mixed populations and males and females needs further investigation.
|
22524828 |
2012 |
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
|
14688021 |
2004 |
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |