Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1002481
rs1002481
0.010 GeneticVariation BEFREE To investigate association between REV3L polymorphisms and lung cancer risk in a Chinese population, we first genotyped 15 common polymorphisms of the REV3L gene and found that three single nucleotide polymorphisms (rs465646, rs459809 and rs1002481) were significantly associated with lung cancer risk. 22349819

2013

dbSNP: rs10040363
rs10040363
0.010 GeneticVariation BEFREE In the replication study of rs10040363, rs1478486, rs9293329, and rs2075685, however, only rs10040363 achieved a borderline association with a decreased risk of lung cancer in a dominant model (adjusted OR=0.80, 95% CI=0.62-1.03 and P=0.079). 21296624

2011

dbSNP: rs10079250
rs10079250
0.010 GeneticVariation BEFREE Our results suggest that the three SNPs, particularly CSF1R rs10079250, may contribute to lung cancer susceptibility in never-smoking females. 25144241

2015

dbSNP: rs10244817
rs10244817
0.010 GeneticVariation BEFREE When stratified by genotype, there was a suggestion of a dose-response relationship between tertiles of telomere length and risk of lung cancer among the POT1 rs10244817 common variant carriers (OR (95% CI)=1.33 (0.47-3.75), 3.30 (1.14-9.56), respectively) but not among variant genotype carriers (p(interaction)=0.05). 19285750

2010

dbSNP: rs10254120
rs10254120
0.010 GeneticVariation BEFREE We further demonstrate that P53 V157D and/or PMS2 R20Q mutant promotes lung cancer cell proliferation. 23981578

2014

dbSNP: rs1042028
rs1042028
0.020 GeneticVariation BEFREE A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. 14688021

2004

dbSNP: rs1042028
rs1042028
0.020 GeneticVariation BEFREE MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively. 22206016

2012

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer. 16287156

2006

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE The variant genotype of TP53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors. 24369748

2014

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE African Americans with Pro-T-A-G-G haplotypes of the combined TP53 polymorphisms TP53_01 (rs1042522), TP53_65 (rs9895829), TP53_66 (rs2909430), TP53_16 (rs1625895), and TP53_11 (rs12951053) had both an increased risk for lung cancer (odds ratio, 2.32; 95% confidence interval, 1.18-4.57) and a worsened lung cancer prognosis (hazards ratio, 2.38; 95% confidence interval, 1.38-4.10) compared with those with Arg-T-A-G-T haplotypes. 17301252

2007

dbSNP: rs1045642
rs1045642
0.010 GeneticVariation BEFREE Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy. 26288241

2016

dbSNP: rs1047840
rs1047840
0.010 GeneticVariation BEFREE These results suggest that the EXO1 Glu589Lys polymorphism and its surrounding regions might be genetic susceptibility markers for lung cancer in this study population. 18079015

2008

dbSNP: rs1047972
rs1047972
0.020 GeneticVariation BEFREE The variant allele of Val57Ile was not associated with lung cancer risk overall. 16926177

2007

dbSNP: rs1047972
rs1047972
0.020 GeneticVariation BEFREE In summary, this meta-analysis suggests that STK15 F31I polymorphism is associated with increased breast cancer and ovarian cancer risk among Caucasians, F31I polymorphism is associated with decreased lung cancer risk among Caucasians, and V57I polymorphism is associated with decreased breast cancer risk among Caucasians. 25154511

2015

dbSNP: rs10487372
rs10487372
0.010 GeneticVariation BEFREE Individuals with 'deletion-T' (DeltaF508/rs10487372) haplotype had a 68% reduced risk for lung cancer compared to common haplotype 'no-deletion-C' (OR=0.32; 95% CI=0.15-0.68; p=0.01). 20116881

2010

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE Neither CYP1A1 MspI nor CYP1A1 Ile(462)Val was associated with lung cancer susceptibility among Caucasians or African-Americans. 16051642

2006

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE The CYP1A1*2B allele (carrying MspI and Ile462Val mutations) was strongly associated with high lung cancer risk (OR = 4.59, CI:1.4-12.6, p <0.01). 20804547

2011

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE An elevated risk of lung cancer was observed among individuals with the MspI CC (OR=1.7, 95 CI=0.9-3.3) and Ile(462)Val ValVal genotypes (OR=2.8, 95 CI=1.1-7.6). 15953982

2005

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE Our results indicate that the CYP1A1*2B allele (rs4646903 and rs1048943) is associated with an increased lung cancer risk and CYP2A6*4 is associated with a decreased lung cancer risk in the study population. 23178447

2013

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of having lung cancer compared to those with the lle/lle genotype, after adjusting for age at diagnosis, sex, pack years of smoking and family history of cancer (OR=0.41 95% Cl 0.19-0.90). 17174438

2007

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphism (Ile/Val, Val/Val) was 2.99 [95% confidence interval (95%CI) 1.51-5.91]; this effect was stronger on lung adenocarcinoma (OR 4.85, 95%CI 2.03-11.6). 12771031

2003

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. 18463401

2008

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. 22952673

2013

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa. 9610791

1999

dbSNP: rs1048943
rs1048943
0.100 GeneticVariation BEFREE CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. 11008920

2001