|
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk.
|
12692111 |
2003 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control study of 1091 Caucasian lung cancer patients and 1240 controls, we explored the gene-environment interactions between the XRCC1 Arg399Gln polymorphism, alone or in combination with the two ERCC2 polymorphisms, and cumulative smoking exposure in the development of lung cancer.
|
12692111 |
2003 |
|
rs759412116
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control study of 1091 Caucasian lung cancer patients and 1240 controls, we explored the gene-environment interactions between the XRCC1 Arg399Gln polymorphism, alone or in combination with the two ERCC2 polymorphisms, and cumulative smoking exposure in the development of lung cancer.
|
12692111 |
2003 |
|
rs17655
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer.
|
12869423 |
2003 |
|
rs121965039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To probe the mechanism of carcinogenesis of lung cancer at the molecular level and to find potential protein markers involved in the early phase of tumorgenesis, differential proteome analysis on primary passage cell line R15H, and early transformed cell line R15H20 derived from (238)Pu alpha-particle irradiation of human papillomavirus (HPV) 18-immortalized human bronchial epithelial cell line (BEP2D), was carried out using two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF) with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.
|
12548635 |
2003 |
|
rs146755810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To probe the mechanism of carcinogenesis of lung cancer at the molecular level and to find potential protein markers involved in the early phase of tumorgenesis, differential proteome analysis on primary passage cell line R15H, and early transformed cell line R15H20 derived from (238)Pu alpha-particle irradiation of human papillomavirus (HPV) 18-immortalized human bronchial epithelial cell line (BEP2D), was carried out using two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF) with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.
|
12548635 |
2003 |
|
rs63750447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To our knowledge, this is for the first time that the T1151A mutation is found in lung cancer.
|
12874865 |
2003 |
|
rs1048943
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our case-control study of lung cancer among women in northeast China revealed an elevated risk associated with the CYP1A1 I462V genotype, but no interaction with smoking or indoor air pollution was found.
|
15363546 |
2004 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the hOGG1 Ser326Cys polymorphism plays an important role in the risk for lung cancer and is linked to exposure to tobacco smoke.
|
15077011 |
2004 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure.
|
15044328 |
2004 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
|
14981981 |
2004 |
|
rs13181
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among men, carriers of the variant allele of XPD Lys751Gln</span> had a non-significantly increased risk of lung cancer</span> in the youngest age interval (RR=6.38, 95% CI=0.74-54.90).
|
14757194 |
2004 |
|
rs13181
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a population-based case-cohort study where cases and the subcohort sample were matched on duration of smoking, we investigated the occurrence of lung cancer and histological subtypes of lung cancer in relation to deletion polymorphism in both GSTM1 and GSTT1, single nucleotide polymorphisms (SNPs) in GSTP1 (Ile105Val and Ala114Val) and a 3 base pair deletion polymorphism in GSTM3.
|
15069685 |
2004 |
|
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case-cohort study, we have investigated the occurrence of lung cancer in relation to a high-risk haplotype, previously identified for breast cancer among post-menopausal women, and in relation to the closely linked polymorphisms XPD Asp312Asn and Lys751Gln.
|
14757194 |
2004 |
|
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure.
|
15044328 |
2004 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations were found between the polymorphisms OGG1 Ser326Cys, XRCC1 Arg280His, and XRCCI Arg399Gln and risk of lung cancer.
|
15587988 |
2004 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations were found between the polymorphisms OGG1 Ser326Cys, XRCC1 Arg280His, and XRCCI Arg399Gln and risk of lung cancer.
|
15587988 |
2004 |
|
rs759412116
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs861539
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs4880
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |