|
rs11466353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of different rs7459185/rs11466353 genotypes in LC patients associated with RIET risk and may be useful biomarkers along with other risk factors for guiding therapy intensity in an individualized therapy.
|
31015163 |
2019 |
|
rs115510139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our results, we observed that rs115510139 was linked to an increased risk of lung cancer in the codominant (adjusted OR = 1.61, 95%CI: 1.14-2.27, p = 0.007), dominant (adjusted OR = 1.36, 95%CI: 1.02-1.83, p = 0.037), recessive (adjusted OR = 1.41, 95%CI: 1.07-1.85, p = 0.015), and log-additive (adjusted OR = 1.27, 95%CI: 1.07-1.51, p = 0.006) models.
|
31286980 |
2019 |
|
rs11658063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele at rs336958 on 5q14.3 was associated with increased lung cancer risk (OR = 1.47; 95% CI, 1.22-1.78), whereas the minor allele at rs11658063 on 17q12 was associated with reduced risk (OR = 0.80; 95% CI, 0.72-0.90).
|
30894353 |
2019 |
|
rs118137916
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, AGAA haplotype (rs10213865, rs969129, rs118137916 and rs10053847) increased LC risk (OR =1.30, <i>P</i>=0.041).
|
31354347 |
2019 |
|
rs121913240
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To begin with, we developed a pipeline to utilize a set of computational tools in order to obtain the most deleterious nsSNPs (Q22K, Q61P, and Q61R) associated with lung cancer in the human KRAS gene.
|
31117243 |
2019 |
|
rs121917737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Surfactant protein A2 mutations (G231V and F198S) have been identified to be associated with pulmonary fibrosis and lung cancer, and these mutations cause protein aggregation, instability as well as secretion deficiency.
|
31546020 |
2019 |
|
rs121917738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Surfactant protein A2 mutations (G231V and F198S) have been identified to be associated with pulmonary fibrosis and lung cancer, and these mutations cause protein aggregation, instability as well as secretion deficiency.
|
31546020 |
2019 |
|
rs12569923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification analysis, the results showed that IL2RA rs12569923 (non-smokers), IL2RA rs791588 (≤60 years old, non-drinkers, BMI < 24 kg/m<sup>2</sup>), IL2RA rs12722498 (≤60 years old, non-drinkers, BMI < 24 kg/m<sup>2</sup>, female) and IL2RB rs2281089 (female, stage) significantly decreased the risk of lung cancer.
|
31279323 |
2019 |
|
rs12674822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five Ang2 SNPs (rs2442598, rs734701, rs1823375, 11137037, and rs12674822</span>) were analyzed using TaqMan SNP genotyping in 695 patients with lung cancer and 900 cancer-free controls.
|
31281470 |
2019 |
|
rs12722498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that IL2RA rs12722498 was significantly associated with a decreased risk of lung cancer in dominant (p = 0.040, OR = 0.71, 95% CI = 0.51-0.98), additive (p = 0.016, OR = 0.68, 95% CI = 0.50-0.93) and allele (p = 0.019, OR = 0.69, 95% CI = 0.51-0.94) models.
|
31279323 |
2019 |
|
rs13032404
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When analyzed for the association with lung squamous carcinoma, rs13032404, rs115510139 and rs3736341 were related to the risk of lung cancer.
|
31286980 |
2019 |
|
rs1323040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
|
30455395 |
2019 |
|
rs144779807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs1489758
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs1489759 and rs3131837 were associated with lung cancer in various genetic models. rs1489758, rs1489759, and rs10519717 were also associated with lung cancer in serious COPD patients.
|
29915314 |
2019 |
|
rs1489759
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs1489759 and rs3131837 were associated with lung cancer in various genetic models. rs1489758, rs1489759, and rs10519717 were also associated with lung cancer in serious COPD patients.
|
29915314 |
2019 |
|
rs1560642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05).
|
31685439 |
2019 |
|
rs1600249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our eQTL analysis finally detected three lncRNA-eQTLs, rs793544 in 3q13.12 (odds ratio [OR] = 1.15; confidence interval [CI]:1.09-1.22; P = 2.30 × 10<sup>-6</sup> ), rs7234707 in 18p11.31 (OR = 1.1; CI:1.05-1.15; P = 9.01 × 10<sup>-5</sup> ) and rs1600249 in 8p23.1 (OR = 1.1; CI:1.05-1.16; P = 1.27 × 10<sup>-4</sup> ), that were consistently associated with the risk of lung cancer.
|
31026380 |
2019 |
|
rs1654701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We checked the interaction effect on the ANGPT1 expression and lung cancer and found that the minor allele "G" of rs1654701 increased ANGPT1 gene expression and decreased lung cancer risk with the increased dosage of "A" of rs4262299, which consistent with the tumor suppressor function of ANGPT1.
|
31385379 |
2019 |
|
rs16901904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-<i>PCAT1</i> (rs1026411 G>A, rs12543663 A>C, rs710886 T>C, and rs16901904 T>C) to investigate the association between genetic variant in lncRNA-<i>PCAT1</i> and susceptibility to lung cancer.
|
31464517 |
2019 |
|
rs1718125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.
|
30762755 |
2019 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
|
30455395 |
2019 |
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs186332
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 × 10-7) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 × 10-6) showed significant association with lung cancer risk.
|
30590402 |
2019 |
|
rs200487215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, a DNA-rN1-DNA-mediated surface-enhanced Raman scattering frequency shift assay is developed, which enables sensitive detection of ctDNA with one single base pair mutation (KARS G12D mutation) from the normal ones (KARS G12D normal) of lung cancer.
|
31050289 |
2019 |
|
rs2043449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.
|
31264381 |
2019 |