|
rs1663689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found genome-wide significant (P < 5.0 × 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10(-8)).
|
22797725 |
2012 |
|
rs1814343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs10750417 and rs1814343 polymorphisms were not significantly associated with lung cancer risks.
|
29878850 |
2018 |
|
rs1862214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis, and that PDCD5 may represent a novel tumor suppressor gene influencing lung cancer.
|
16549820 |
2006 |
|
rs2736107
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms exhibited prominent associations with lung cancer risk, including rs7726159 (OR = 1.34, 95%CI: 1.18-1.52, P = 7.78 × 10<sup>-6</sup> ), rs10054203 (OR = 1.29, 95%CI: 1.13-1.46, P = 1.37 × 10<sup>-4</sup> ), rs2736107 (OR = 1.28, 95%CI: 1.11-1.47, P = 5.14 × 10<sup>-4</sup> ), and rs2853677 (OR = 1.23, 95%CI: 1.08-1.39, P = 0.002).
|
30680798 |
2019 |
|
rs2736108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
|
rs2794520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CRP rs2794520 (OR=1.64, 95% CI=1.19-2.26) and IL6 rs1800796 (OR=1.41, 95% CI=1.02-1.96) were associated with lung cancer risk.
|
24139238 |
2014 |
|
rs2924471
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
|
23372658 |
2013 |
|
rs35755165
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When conditioning on nine known functional variants and two deletions, the top two SNPs (rs56113850 in MEC and rs35755165 in TRICL) remained significantly associated with CYP2A6 activity in MEC and lung cancer in TRICL.
|
27488534 |
2016 |
|
rs36115365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity.
|
28447668 |
2017 |
|
rs3742038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.
|
30065613 |
2018 |
|
rs3856776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
What's more, rs3856776 was newly identified and might modulate lung cancer susceptibility by suppressing the function of <i>LEPREL1</i>.
|
31205543 |
2019 |
|
rs4105144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine).
|
21862624 |
2011 |
|
rs4665162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of RP in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP.
|
26449830 |
2016 |
|
rs4769793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STAT3 rs4769793 G allele carriers had an increased susceptibility of lung cancer [additive model: adjusted OR (95% CI) 1.376 (1.058-1.789), P = 0.017; recessive model: adjusted OR (95% CI) 1.734 (1.007-2.985), P = 0.047].
|
30689078 |
2019 |
|
rs4785367
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for rs4785367, compared with homozygous TT, homozygous CC could lessen the risk of lung cancer (adjusted OR = 0.54, 95% CI = 0.33-0.89, p = 0.016).
|
29878850 |
2018 |
|
rs4912913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression revealed that four variants in NR3C1 and SATB1 were significantly associated with lung cancer risk after false discovery rate (FDR) correction [For NR3C1, rs9324921: odds ratio (OR)=1.23, P for FDR=0.029; rs12521436: OR=0.85, P for FDR=0.040; rs4912913: OR=1.17, P for FDR=0.040; For SATB1, rs6808523: OR=1.33, P for FDR=0.040].
|
27179949 |
2016 |
|
rs505974
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene-set enrichment and pathway analysis revealed that rs505974 may affect the susceptibility to lun</span>g cancer via regulating the expression of CLDN16, which may be involved in the chemical carcinogenesis pathway, whereas rs79589812 may regulate the expression of SPATC1L, which may be involved in the base excision repair pathway.
|
30689816 |
2019 |
|
rs568404
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-12A rs568404 AA genotype may contribute to the etiology and serve as a genomic determinant of lung cancer in Taiwanese, especially smokers.
|
30396953 |
2018 |
|
rs5756523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis showed that rs1042711 and rs1560642 were associated with increased risk of lung cancer i</span>n nonsmokers and smokers, respectively, whereas rs7025417 and rs5756523 were associated with decreased disease risk in both subgroups (p＜0.05).
|
31685439 |
2019 |
|
rs7248167
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two polymorphisms (rs2854509 and rs7248167) that were predicted to affect XRCC1 expression based on their RegulomeDB scores were not associated with lung cancer risk (P = 0.31 and 0.93, respectively).
|
25592768 |
2015 |
|
rs7452888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lung cancer patients who were never-smokers, based on a small sample.
|
21750227 |
2011 |
|
rs7459185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of single nucleotide polymorphisms at HSPB1 rs7459185 and TGFB1 rs11466353 with radiation esophagitis in lung cancer.
|
31015163 |
2019 |
|
rs793544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our eQTL analysis finally detected three lncRNA-eQTLs, rs793544 in 3q13.12 (odds ratio [OR] = 1.15; confidence interval [CI]:1.09-1.22; P = 2.30 × 10<sup>-6</sup> ), rs7234707 in 18p11.31 (OR = 1.1; CI:1.05-1.15; P = 9.01 × 10<sup>-5</sup> ) and rs1600249 in 8p23.1 (OR = 1.1; CI:1.05-1.16; P = 1.27 × 10<sup>-4</sup> ), that were consistently associated with the risk of lung cancer.
|
31026380 |
2019 |
|
rs7959801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk.
|
30065613 |
2018 |
|
rs7959801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the rs7959801T>C polymorphism in the MSI1 promoter conferred a decreased risk to lung cancer by reducing the expression of MSI1 and it may be a promising indicator for lung cancer predisposition.
|
30065613 |
2018 |