Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1663689
rs1663689
0.010 GeneticVariation BEFREE We found genome-wide significant (P < 5.0 × 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10(-8)). 22797725

2012

dbSNP: rs1814343
rs1814343
0.010 GeneticVariation BEFREE However, rs10750417 and rs1814343 polymorphisms were not significantly associated with lung cancer risks. 29878850

2018

dbSNP: rs1862214
rs1862214
0.010 GeneticVariation BEFREE These results suggest that the rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis, and that PDCD5 may represent a novel tumor suppressor gene influencing lung cancer. 16549820

2006

dbSNP: rs2736107
rs2736107
0.010 GeneticVariation BEFREE Four polymorphisms exhibited prominent associations with lung cancer risk, including rs7726159 (OR = 1.34, 95%CI: 1.18-1.52, P = 7.78 × 10<sup>-6</sup> ), rs10054203 (OR = 1.29, 95%CI: 1.13-1.46, P = 1.37 × 10<sup>-4</sup> ), rs2736107 (OR = 1.28, 95%CI: 1.11-1.47, P = 5.14 × 10<sup>-4</sup> ), and rs2853677 (OR = 1.23, 95%CI: 1.08-1.39, P = 0.002). 30680798

2019

dbSNP: rs2736108
rs2736108
0.010 GeneticVariation BEFREE In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively). 23908149

2013

dbSNP: rs2794520
rs2794520
0.010 GeneticVariation BEFREE CRP rs2794520 (OR=1.64, 95% CI=1.19-2.26) and IL6 rs1800796 (OR=1.41, 95% CI=1.02-1.96) were associated with lung cancer risk. 24139238

2014

dbSNP: rs2924471
rs2924471
0.010 GeneticVariation BEFREE SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers. 23372658

2013

dbSNP: rs35755165
rs35755165
0.010 GeneticVariation BEFREE When conditioning on nine known functional variants and two deletions, the top two SNPs (rs56113850 in MEC and rs35755165 in TRICL) remained significantly associated with CYP2A6 activity in MEC and lung cancer in TRICL. 27488534

2016

dbSNP: rs36115365
rs36115365
0.010 GeneticVariation BEFREE Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. 28447668

2017

dbSNP: rs3742038
rs3742038
0.010 GeneticVariation BEFREE Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk. 30065613

2018

dbSNP: rs3856776
rs3856776
0.010 GeneticVariation BEFREE What's more, rs3856776 was newly identified and might modulate lung cancer susceptibility by suppressing the function of <i>LEPREL1</i>. 31205543

2019

dbSNP: rs4105144
rs4105144
0.010 GeneticVariation BEFREE Two 19q13 variants, rs7937 and rs4105144, were associated with increased cotinine (P = 0.003 and P < 0.001, respectively) but decreased lung cancer risk (P = 0.01 for both, after adjusting for cotinine). 21862624

2011

dbSNP: rs4665162
rs4665162
0.010 GeneticVariation BEFREE Our results showed that AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of RP in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP. 26449830

2016

dbSNP: rs4769793
rs4769793
0.010 GeneticVariation BEFREE STAT3 rs4769793 G allele carriers had an increased susceptibility of lung cancer [additive model: adjusted OR (95% CI) 1.376 (1.058-1.789), P = 0.017; recessive model: adjusted OR (95% CI) 1.734 (1.007-2.985), P = 0.047]. 30689078

2019

dbSNP: rs4785367
rs4785367
0.010 GeneticVariation BEFREE As for rs4785367, compared with homozygous TT, homozygous CC could lessen the risk of lung cancer (adjusted OR = 0.54, 95% CI = 0.33-0.89, p = 0.016). 29878850

2018

dbSNP: rs4912913
rs4912913
0.010 GeneticVariation BEFREE Logistic regression revealed that four variants in NR3C1 and SATB1 were significantly associated with lung cancer risk after false discovery rate (FDR) correction [For NR3C1, rs9324921: odds ratio (OR)=1.23, P for FDR=0.029; rs12521436: OR=0.85, P for FDR=0.040; rs4912913: OR=1.17, P for FDR=0.040; For SATB1, rs6808523: OR=1.33, P for FDR=0.040]. 27179949

2016

dbSNP: rs505974
rs505974
0.010 GeneticVariation BEFREE Gene-set enrichment and pathway analysis revealed that rs505974 may affect the susceptibility to lung cancer via regulating the expression of CLDN16, which may be involved in the chemical carcinogenesis pathway, whereas rs79589812 may regulate the expression of SPATC1L, which may be involved in the base excision repair pathway. 30689816

2019

dbSNP: rs568404
rs568404
0.010 GeneticVariation BEFREE IL-12A rs568404 AA genotype may contribute to the etiology and serve as a genomic determinant of lung cancer in Taiwanese, especially smokers. 30396953

2018

dbSNP: rs5756523
rs5756523
0.010 GeneticVariation BEFREE Stratification analysis showed that rs1042711 and rs1560642 were associated with increased risk of lung cancer in nonsmokers and smokers, respectively, whereas rs7025417 and rs5756523 were associated with decreased disease risk in both subgroups (p<0.05). 31685439

2019

dbSNP: rs7248167
rs7248167
0.010 GeneticVariation BEFREE Two polymorphisms (rs2854509 and rs7248167) that were predicted to affect XRCC1 expression based on their RegulomeDB scores were not associated with lung cancer risk (P = 0.31 and 0.93, respectively). 25592768

2015

dbSNP: rs7452888
rs7452888
0.010 GeneticVariation BEFREE However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lung cancer patients who were never-smokers, based on a small sample. 21750227

2011

dbSNP: rs7459185
rs7459185
0.010 GeneticVariation BEFREE Association of single nucleotide polymorphisms at HSPB1 rs7459185 and TGFB1 rs11466353 with radiation esophagitis in lung cancer. 31015163

2019

dbSNP: rs793544
rs793544
0.010 GeneticVariation BEFREE Our eQTL analysis finally detected three lncRNA-eQTLs, rs793544 in 3q13.12 (odds ratio [OR] = 1.15; confidence interval [CI]:1.09-1.22; P = 2.30 × 10<sup>-6</sup> ), rs7234707 in 18p11.31 (OR = 1.1; CI:1.05-1.15; P = 9.01 × 10<sup>-5</sup> ) and rs1600249 in 8p23.1 (OR = 1.1; CI:1.05-1.16; P = 1.27 × 10<sup>-4</sup> ), that were consistently associated with the risk of lung cancer. 31026380

2019

dbSNP: rs7959801
rs7959801
0.010 GeneticVariation BEFREE Based on a two-stage retrospective study with a total of 1559 patients with lung cancer and 1667 healthy controls, we evaluated the relevance between three putative functional SNPs in the MSI1 promoter (i.e., -2696T>C[rs7959801], -2297T>C[rs3742038] and -1081C>T[rs34570155]) and lung cancer risk. 30065613

2018

dbSNP: rs7959801
rs7959801
0.010 GeneticVariation BEFREE Our findings suggested that the rs7959801T>C polymorphism in the MSI1 promoter conferred a decreased risk to lung cancer by reducing the expression of MSI1 and it may be a promising indicator for lung cancer predisposition. 30065613

2018