|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy.
|
26288241 |
2015 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 S112T; GSTM3 V224I and MTHFR A222V had altered risk of developing lung cancer.
|
17259654 |
2007 |
|
rs2032582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.
|
17120199 |
2006 |
|
rs2032582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
|
30455395 |
2019 |
|
rs1128503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
|
30455395 |
2019 |
|
rs149518139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 S112T; GSTM3 V224I and MTHFR A222V had altered risk of developing lung cancer.
|
17259654 |
2007 |
|
rs2188524
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping analyses for 6 common regulatory variants (reference single-nucleotide polymorphism 4728709 [rs4728709] and rs2188524 in the 5' flanking region of ABCB1 and rs3842 in its 3' untranslated region; rs3743527, rs212090, and rs212091 in the 3' untranslated region of ABCC1) was conducted in a case-control study of 500 patients with incident lung cancer and 517 cancer-free controls in a Chinese population.
|
19107762 |
2009 |
|
rs2235013
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chemotherapy and stage jointly (p = 0.025) significantly modified the association between rs2235013 and survival, with statistically significant (p = 0.013, log-rank test) association observed in the subgroup of stage III to IV lung cancer patients who received chemotherapy as part of their first course of treatment (n = 160; 93.1% nonsmall cell).
|
25122423 |
2014 |
|
rs3842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with the wild adenosine/adenosine (A/A) genotype, the variant rs3842 genotype (adenosine/guanosine [A/G] + G/G) of ABCB1 was associated with a statistically significant increased risk of developing lung cancer (odds ratio [OR].
|
19107762 |
2009 |
|
rs212091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping analyses for 6 common regulatory variants (reference single-nucleotide polymorphism 4728709 [rs4728709] and rs2188524 in the 5' flanking region of ABCB1 and rs3842 in its 3' untranslated region; rs3743527, rs212090, and rs212091 in the 3' untranslated region of ABCC1) was conducted in a case-control study of 500 patients with incident lung cancer and 517 cancer-free controls in a Chinese population.
|
19107762 |
2009 |
|
rs4148356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population, especially in older people.
|
21736601 |
2011 |
|
rs2231142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this study prioritizes ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients.
|
19107936 |
2009 |
|
rs9912300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model.
|
25227797 |
2014 |
|
rs11896604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
|
27974682 |
2016 |
|
rs1682111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
|
27974682 |
2016 |
|
rs843720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
|
27974682 |
2016 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
rs1042711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05).
|
31685439 |
2019 |
|
rs4513061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant impact was not observed between the rs4513061 polymorphism and survival time of lung cancer.
|
31603707 |
2019 |
|
rs2070600
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In subgroup analysis for 82G/S, a significantly elevated cancer risk was indicated in the population of Asian and patients with lung cancer, and for -374T/A, reduced risk was indicated in population of Caucasian and patients with lung cancer and breast cancer.
|
25603950 |
2015 |
|
rs2070600
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings provide evidence that the variant A allele of rs2070600 may decrease the expression of the tumour suppressor gene RAGE, thereby increasing lung cancer risk.
|
29421442 |
2018 |
|
rs2070600
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Haplotype C-A-A (alleles in order of rs1800625, rs1800624 and rs2070600) of RAGE gene was overrepresented in patients, and conferred a 2.1-fold increased risk of lung cancer (95% confidence interval: 1.52-2.91), independent of confounding factors.
|
23874853 |
2013 |
|
rs2070600
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The polymorphism of rs2070600 in the RAGE gene may increase the susceptibility to several human cancers, especially to lung cancer and to Asians.
|
26011358 |
2015 |
|
rs1800624
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the gene encoding RAGE (<i>AGER</i>), there are three well-known polymorphisms; rs2070600, rs1800624, and rs1800625, which potentially increase the risk of lung cancer.
|
29212235 |
2017 |
|
rs1800624
|
|
|
0.030 |
GeneticVariation |
BEFREE |
But in subgroup analysis, the rs1800624 polymorphism significantly increased lung cancer susceptibility in the homozygous model (OR=1.486, 95%CI:1.147-1.924, p=0.003) and the allele model (OR=1.15, 95%CI:1.029-1.285, p=0.014), but most likely contributed to decreased susceptibility to breast cancer in the allele model (OR=0.791 95%CI: 0.648-0.965, p=0.021), the heterozygous model (OR=0.733, 95%CI:0.577-0.931, p=0.011) and the dominant model (OR=0.741, 95%CI:0.588-0.934, p=0.011).
|
26011358 |
2015 |