|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis shows that the polymorphism of APE1 Asp148Glu exerts risk effect on lung cancer development.
|
24523018 |
2014 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer.
|
24705777 |
2014 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This updated meta-analysis suggests that the APE1 Asp148Glu polymorphisms are not associated with lung cancer risk among Asians or Caucasians.
|
24310503 |
2014 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs1130409 of APEX1 can be a predictor of RP grades ≥3 among patients with lung cancer.
|
24884729 |
2014 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results provide evidence that the non-synonymous polymorphis</span>m of APEX1 Asp(148)Glu may not be directly associated with lung cancer</span> risk, nor enhance the effects of smoking habit on lung cancer development.
|
23749940 |
2013 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 Ser326Cys polymorphism is associated with lung cancer risk, but there are limited data regarding an association between the APE1 Asp148Glu polymorphism and lung cancer.
|
23038158 |
2012 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a study with the larger sample size is needed to further evaluated gene-environment interaction on OGG1 Ser326Cys and APEX1 Asp14</span>8Glu polymorphisms and lung cancer risk.
|
23065211 |
2012 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with lung cancer risk among Asians or Caucasians.
|
21132382 |
2011 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a hospital-based, case-control study of 455 lung cancer cases and 443 cancer-free hospital controls, the SNPs of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their correlation with the risk of lung cancer in multivariate logistic regression models.
|
21722819 |
2011 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined effect of smoking and presence of the APEX1 Asp148Glu demonstrated a significant association with risk of lung cancer (adjusted OR 3.61, 95% CI 1.74-7.50, p=0.001).
|
21198260 |
2010 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Individuals carrying the APE1 Asp148Glu heterozygous and homozygous variant genotype had a 3.23-fold increased risk of lung cancer compared with these carrying the wild-type (Asp/Asp) genotype (p<0.0001), and those carrying the 148Glu homozygous genotype had a 3.17-fold increased risk (p=0.023).
|
19528510 |
2009 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the APE1 Asp148Glu polymorphism is highly predictive for lung cancer, and cumulative cigarette smoking modifies the associations between the XRCC1 Arg399Gln and the XPD Lys751Gln polymorphisms and lung cancer risk.
|
17531525 |
2007 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common APE1 polymorphism, a T-->G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an association that was modified by cigarette smoking.
|
16425270 |
2006 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure.
|
15044328 |
2004 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |