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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The present updated meta-analysis demonstrated that the MTHFR C677T polymorphism was significantly associated with susceptibility to lung cancer in Chinese people.
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31192962 |
2019 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that the <i>MTHFR</i> C677T polymorphism may contribute to the development of lung cancer and lung adenocarcinoma in a female Chinese population.
|
30323671 |
2018 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C Ile349Val, ALDH2 Glu540Lys, CYP2E1 RsaI, CYP2E1 DraI, CYP2E1 TaqI and MTHFR C677T polymorphisms on the risk of developing lung cancer.
|
28236470 |
2017 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis showed that the MTHFR C677T polymorphism is associated with a significant increase in lung cancer risk in Asian and overall populations, but not in Caucasian populations.
|
27173216 |
2016 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The association between MTHFR C677T and A1298C genotype and haplotype frequencies in risk for lung cancer (LC) was investigated in the Jordanian population.
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25921104 |
2015 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
We searched the databases of Medline, PubMed, EMBASE, Wanfang, and CNIK to find the case-control or cohort study about the relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility.
|
26323926 |
2015 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that there was no association between the MTHFR C677T polymorphism and lung cancer in the Turkish population.
|
25124620 |
2014 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis provides evidence that MTHFR C677T polymorphism may contribute to LC development in North China.
|
25544260 |
2014 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism might be a genetic marker for lung cancer risk or response to platinum- based chemotherapy in advanced NSCLC.
|
24142642 |
2013 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The association between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and lung cancer risk has been studied in various populations with conflicting results.
|
23237779 |
2013 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant association was detected between the MTHFR C677T polymorphism and LC risk, the same as in race subgroup.
|
22901166 |
2012 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis supports that the common polymorphisms of C677T and A1298C in MTHFR gene are not susceptibility gene for lung cancer from currently available evidence.
|
22215214 |
2012 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
The current study was performed to assess any association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of lung cancer in Henan province.
|
22938410 |
2012 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
This study was designed to investigate the effects of the polymorphisms of methylenetetrahydrofolate reductase 677 C→T (MTHFR 677 C→T), thymidylate synthase (TYMS 3R→2R),and methionine synthase 2756 A→G (MTR 2756 A→G) on the risk of lung cancer and response to platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC).
|
21605004 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The C677T polymorphism was significantly associated with lung cancer risk.
|
22024018 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
This is the first reported study focusing on the association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population.
|
21342495 |
2011 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Our results provide the first evidence that the C allele of MTHFR C677T may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
|
20065319 |
2010 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer.
|
18789576 |
2009 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The effect of MTHFR polymorphisms (C677T, A1298C) on the risk of lung cancer was undetectable, even though analyzed on a relatively good number of subjects (totally 11,526 subjects) by meta-analysis (statistical power = 93.9%).
|
18340404 |
2008 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
In conclusion, we identified a moderate effect of MTHFR C677T on lung cancer risk and a possible effect modification by folate intake that is consistent with the functional data.
|
17389614 |
2007 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate metabolism and thus might be suspected of impacting on lung cancer risk.
|
17468511 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
|
14981981 |
2004 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, we found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and risk of lung cancer in either all of the subjects or the low folate intake subgroup; nor did we find evidence for an interaction between these two MTHFR polymorphisms and dietary folate intake or alcohol use.
|
11319182 |
2001 |