Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs372043866
rs372043866
0.030 GeneticVariation BEFREE Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer. 26689995

2016

dbSNP: rs372043866
rs372043866
0.030 GeneticVariation BEFREE In preclinical studies, afatinib not only inhibited the growth of models with common activating EGFR mutations, but was also active in lung cancer models harboring wild-type EGFR or the EGFR L858R/T790M double mutant. 23664448

2013

dbSNP: rs372043866
rs372043866
0.030 GeneticVariation BEFREE EGFR mutations (CTG-->CGG; L858R) were found from 14 of 95 lung cancer patients. 16003726

2006

dbSNP: rs1196929947
rs1196929947
0.010 GeneticVariation BEFREE Consistent with this, a G660D germline mutant lung cancer patient showed remarkable clinical response to HER2 blockade. 30449325

2018

dbSNP: rs1057519857
rs1057519857
0.010 GeneticVariation BEFREE Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. 25620423

2015

dbSNP: rs121913469
rs121913469
0.010 GeneticVariation BEFREE Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. 25620423

2015

dbSNP: rs1058808
rs1058808
0.010 GeneticVariation BEFREE In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. 19055823

2008