rs947141826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Up-regulation of small GTP-binding proteins smg P21A and ras P21S during TPA-induced differentiation of human leukemia cell lines.
|
8429689 |
1993 |
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27.
|
11705857 |
2001 |
rs1258094111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs.
|
11705857 |
2001 |
rs765669662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs.
|
11705857 |
2001 |
rs765669662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27.
|
11705857 |
2001 |
rs775144154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs.
|
11705857 |
2001 |
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate.
|
12453860 |
2002 |
rs1800562
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility.
|
12002748 |
2002 |
rs1275561861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility.
|
12002748 |
2002 |
rs387906553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, these data suggest that expression of V72M NE is not sufficient to induce an SCN phenotype or leukemia in mice.
|
12384420 |
2002 |
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this study we describe the genotyping of the MTHFR C677T polymorphism by melting curve analysis with the LightCycler in a case-controlled study of patients with acute lymphocytic leukemia (ALL), myelogenous leukemia (AML), and chronic myelogenous leukemia (CML), and assess the effect of this common polymorphism on the leukemia risk in adult patients in Turkey.
|
15068389 |
2003 |
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated.
|
12827651 |
2003 |
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated.
|
12827651 |
2003 |
rs762613037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The bone marrow and/or peripheral blood from 126 patients with acute myeloid leukemia (AML), 57 with chronic myeloid leukemia (CML), 91 with acute lymphocytic leukemia (ALL), and 178 normal controls were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay to evaluate the association of the endostatin polymorphisms D104N (nucleotide 4349G --> A) with leukemia.
|
12693719 |
2003 |
rs1800562
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Interactions of HFE with environmental and genetic factors, most of which are recognized, may play a role in modification of susceptibility to leu</span>kemia conferred by C282Y.
|
15775751 |
2005 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Homozygous V617F mutation is associated with the clinical picture of classic PV and with a higher tendency to secondary myelofibrosis, but with no increased leukemia unless other biological or genetic factors come into play, such as myelosuppressive agents or the acquisition of additional biologic or genetic defects.
|
16810614 |
2006 |
rs1800562
|
|
|
0.030 |
GeneticVariation |
BEFREE |
HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia.
|
16314188 |
2006 |
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our investigation provides interesting data concerning the opposite effect of A1298C polymorphisms, particularly in the light of relatively scarce data regarding the MTHFR role in leukemia susceptibility in different populations.
|
16182363 |
2006 |
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia.
|
16314188 |
2006 |
rs35602083
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that the FLT3 D324N variant might be associated with a predisposition to different subtypes of leukemia.
|
16320249 |
2006 |
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The incidence of JAK2 V617F in patients with a core binding factor (CBF) leukemia was 3.6% (p<0.01).
|
17229652 |
2007 |
rs121913507
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In attempting to establish a murine model of human KIT(D816V) (hKIT(D816V))-mediated leukemia, we uncovered an unexpected relationship between cellular transformation and intracellular trafficking.
|
17060458 |
2007 |
rs121913682
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In attempting to establish a murine model of human KIT(D816V) (hKIT(D816V))-mediated leukemia, we uncovered an unexpected relationship between cellular transformation and intracellular trafficking.
|
17060458 |
2007 |
rs121434592
|
|
|
0.020 |
GeneticVariation |
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |
rs387906659
|
|
|
0.010 |
GeneticVariation |
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |