Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs947141826
rs947141826
0.010 GeneticVariation BEFREE Up-regulation of small GTP-binding proteins smg P21A and ras P21S during TPA-induced differentiation of human leukemia cell lines. 8429689

1993

dbSNP: rs1051266
rs1051266
0.010 GeneticVariation BEFREE In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27. 11705857

2001

dbSNP: rs1258094111
rs1258094111
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs765669662
rs765669662
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs765669662
rs765669662
0.010 GeneticVariation BEFREE In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27. 11705857

2001

dbSNP: rs775144154
rs775144154
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs1217691063
rs1217691063
0.060 GeneticVariation BEFREE Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate. 12453860

2002

dbSNP: rs1800562
rs1800562
0.030 GeneticVariation BEFREE Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility. 12002748

2002

dbSNP: rs1275561861
rs1275561861
0.010 GeneticVariation BEFREE Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility. 12002748

2002

dbSNP: rs387906553
rs387906553
0.010 GeneticVariation BEFREE Collectively, these data suggest that expression of V72M NE is not sufficient to induce an SCN phenotype or leukemia in mice. 12384420

2002

dbSNP: rs1217691063
rs1217691063
0.060 GeneticVariation BEFREE In this study we describe the genotyping of the MTHFR C677T polymorphism by melting curve analysis with the LightCycler in a case-controlled study of patients with acute lymphocytic leukemia (ALL), myelogenous leukemia (AML), and chronic myelogenous leukemia (CML), and assess the effect of this common polymorphism on the leukemia risk in adult patients in Turkey. 15068389

2003

dbSNP: rs1217691063
rs1217691063
0.060 GeneticVariation BEFREE The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. 12827651

2003

dbSNP: rs1695
rs1695
0.010 GeneticVariation BEFREE The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. 12827651

2003

dbSNP: rs762613037
rs762613037
0.010 GeneticVariation BEFREE The bone marrow and/or peripheral blood from 126 patients with acute myeloid leukemia (AML), 57 with chronic myeloid leukemia (CML), 91 with acute lymphocytic leukemia (ALL), and 178 normal controls were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay to evaluate the association of the endostatin polymorphisms D104N (nucleotide 4349G --> A) with leukemia. 12693719

2003

dbSNP: rs1800562
rs1800562
0.030 GeneticVariation BEFREE Interactions of HFE with environmental and genetic factors, most of which are recognized, may play a role in modification of susceptibility to leu</span>kemia conferred by C282Y. 15775751

2005

dbSNP: rs77375493
rs77375493
0.060 GeneticVariation BEFREE Homozygous V617F mutation is associated with the clinical picture of classic PV and with a higher tendency to secondary myelofibrosis, but with no increased leukemia unless other biological or genetic factors come into play, such as myelosuppressive agents or the acquisition of additional biologic or genetic defects. 16810614

2006

dbSNP: rs1800562
rs1800562
0.030 GeneticVariation BEFREE HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia. 16314188

2006

dbSNP: rs397507444
rs397507444
0.020 GeneticVariation BEFREE Our investigation provides interesting data concerning the opposite effect of A1298C polymorphisms, particularly in the light of relatively scarce data regarding the MTHFR role in leukemia susceptibility in different populations. 16182363

2006

dbSNP: rs1799945
rs1799945
0.010 GeneticVariation BEFREE HFE-codon 63/282 (H63D/C282Y) gene variants in Mexican Mestizos are not risk factors for leukemia. 16314188

2006

dbSNP: rs35602083
rs35602083
0.010 GeneticVariation BEFREE Our data suggest that the FLT3 D324N variant might be associated with a predisposition to different subtypes of leukemia. 16320249

2006

dbSNP: rs77375493
rs77375493
0.060 GeneticVariation BEFREE The incidence of JAK2 V617F in patients with a core binding factor (CBF) leukemia was 3.6% (p<0.01). 17229652

2007

dbSNP: rs121913507
rs121913507
KIT
0.040 GeneticVariation BEFREE In attempting to establish a murine model of human KIT(D816V) (hKIT(D816V))-mediated leukemia, we uncovered an unexpected relationship between cellular transformation and intracellular trafficking. 17060458

2007

dbSNP: rs121913682
rs121913682
KIT
0.040 GeneticVariation BEFREE In attempting to establish a murine model of human KIT(D816V) (hKIT(D816V))-mediated leukemia, we uncovered an unexpected relationship between cellular transformation and intracellular trafficking. 17060458

2007

dbSNP: rs121434592
rs121434592
0.020 GeneticVariation BEFREE They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice. 17921701

2007

dbSNP: rs387906659
rs387906659
0.010 GeneticVariation BEFREE They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice. 17921701

2007