|
rs121913507
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia.
|
25247397 |
2015 |
|
rs121913682
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia.
|
25247397 |
2015 |
|
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system.
|
29967475 |
2018 |
|
rs121913514
|
|
|
0.030 |
GeneticVariation |
BEFREE |
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells.
|
31484543 |
2019 |
|
rs61754966
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally we confirmed the higher incidence of the p.I171V mutation in the leukemia group (7/220) than among controls (12/2400) (p<0.0001).
|
24093751 |
2013 |
|
rs138817062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, little is known about the underlying mechanisms by which HIPK2 mutations are associated with the pathogenesis of leukemia.
|
30755814 |
2019 |
|
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although many imatinib-resistant mutations respond well to second-generation TKIs, the threonine-to-isoleucine mutation at codon 315 of the breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene protein fusion Bcr-Abl (T315I) is insensitive to all currently available TKIs.
|
20564073 |
2010 |
|
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although strategies to overcome resistance-mediated T315I mutation may improve the survival of BCR-ABL-positive leukemia patients, there is little information on cell-based studies.
|
20471447 |
2010 |
|
rs77375493
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Among the patients with myelofibrosis, those with ASXL1 lesions were not distinguished from their wild-type counterparts with regard to JAK2 V617F status, exposure to chemotherapy or evolution to leukemia.
|
21712540 |
2011 |
|
rs2736098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the probands, a significantly increased frequency of leukemia was found in the carriers of SNP rs2736098 (5p15, P = .03) and melanoma in the carriers of either SNP rs1512268 (8p21, P = .006) or SNP rs5759167 (22q13, P = .02).
|
21820706 |
2011 |
|
rs61754966
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among these, an association with cancer was found most frequently for 657del5 (in leukemia/lymphoma and breast cancer) and I171V (in leukemia, breast, head and neck and colorectal cancers); however, other studies gave contradictory results.
|
18606567 |
2008 |
|
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells.
|
29321163 |
2018 |
|
rs121913521
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia.
|
25247397 |
2015 |
|
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Collectively, the present results suggest that in the treatment of leukemia, taxodione has potential as a compound with high efficacy to overcome BCR-ABL T315I mutation-mediated resistance in leukemia cells.
|
29859988 |
2018 |
|
rs1360131632
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Collectively, the present results suggest that in the treatment of leukemia, taxodione has potential as a compound with high efficacy to overcome BCR-ABL T315I mutation-mediated resistance in leukemia cells.
|
29859988 |
2018 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Collectively, the results of the present study suggest that XRCC1 Arg399Gln polymorphism might be a low-penetrant risk factor for leukemia, particularly among Asians.
|
23990457 |
2014 |
|
rs387906553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, these data suggest that expression of V72M NE is not sufficient to induce an SCN phenotype or leukemia in mice.
|
12384420 |
2002 |
|
rs3116496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS Our meta-analysis confirmed that rs3116496 was significantly related to cancer risk, especially in an Asian population, and was strongly correlated with the increased risk of breast cancer, leukemia and colorectal cancer.
|
30867406 |
2019 |
|
rs121913502
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conditional deletion of IDH2/R140Q blocked 2-HG production and maintenance of leukemia stem cells, resulting in survival of the AML mice.
|
25795706 |
2015 |
|
rs121913507
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Dasatinib overrides the differentiation blockage in a patient with mutant-<i>KIT</i> D816V positive CBFβ-MYH11 leukemia.
|
29545943 |
2018 |
|
rs121913682
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Dasatinib overrides the differentiation blockage in a patient with mutant-<i>KIT</i> D816V positive CBFβ-MYH11 leukemia.
|
29545943 |
2018 |
|
rs1408538785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from cord blood cells and leukemia cell lines suggest a role for DDX41 in preribosomal RNA processing, in which the expression of the p.R525H mutant causes a certain ribosomopathy phenotype in hematopoietic cells by suppressing MDM2-mediated RB degradation, thus triggering the inhibition of E2F activity.
|
27174803 |
2016 |
|
rs869312828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from cord blood cells and leukemia cell lines suggest a role for DDX41 in preribosomal RNA processing, in which the expression of the p.R525H mutant causes a certain ribosomopathy phenotype in hematopoietic cells by suppressing MDM2-mediated RB degradation, thus triggering the inhibition of E2F activity.
|
27174803 |
2016 |
|
rs1360698171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of xenotropic murine leukemia virus and its R426Q polymorphism in patients with prostate cancer in Kerman, southeast of Iran.
|
23098452 |
2012 |
|
rs1057519766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
|
23878140 |
2013 |