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rs974120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
|
rs1408538785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from cord blood cells and leukemia cell lines suggest a role for DDX41 in preribosomal RNA processing, in which the expression of the p.R525H mutant causes a certain ribosomopathy phenotype in hematopoietic cells by suppressing MDM2-mediated RB degradation, thus triggering the inhibition of E2F activity.
|
27174803 |
2016 |
|
rs174538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, it has not been revealed whether rs174538 and rs4246215 are associated with leukemia.
|
26708601 |
2016 |
|
rs1801157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to determine the associations between the polymorphisms located on the SDF-1 (rs1801157, G>A) and CXCR4 (rs2228014, C>T) encoding genes and susceptibility and leukemia cell dissemination in AML.
|
27154815 |
2016 |
|
rs201045130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While investigating leukemia susceptibility genes, we discovered a very rare p.L254P NT5C1A missense variant in the substrate recognition motif.
|
26906009 |
2016 |
|
rs2228014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to determine the associations between the polymorphisms located on the SDF-1 (rs1801157, G>A) and CXCR4 (rs2228014, C>T) encoding genes and susceptibility and leukemia cell dissemination in AML.
|
27154815 |
2016 |
|
rs3184504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LNK (R262W) is a loss-of-function variant that promotes thrombopoietin/myeloproliferative leukemia virus oncogene signaling and platelet and leukocyte production.
|
27430239 |
2016 |
|
rs4246215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, it has not been revealed whether rs174538 and rs4246215 are associated with leukemia.
|
26708601 |
2016 |
|
rs869312828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from cord blood cells and leukemia cell lines suggest a role for DDX41 in preribosomal RNA processing, in which the expression of the p.R525H mutant causes a certain ribosomopathy phenotype in hematopoietic cells by suppressing MDM2-mediated RB degradation, thus triggering the inhibition of E2F activity.
|
27174803 |
2016 |
|
rs121913452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with Philadelphia-positive leukemia with Y253H or F359V mutation have a high risk of developing new mutations in the setting of dasatinib resistance.
|
25379619 |
2015 |
|
rs121913461
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that patients with Ph+ leukemia with Y253H or F359V mutation have a high likelihood of developing new mutations in the setting of dasatinib resistance.
|
25379619 |
2015 |
|
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
rs138213197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer.
|
26108461 |
2015 |
|
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
rs2228001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study we aimed to evaluate the associations between XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181) and XPG Asp1104His (rs17655) polymorphisms and leukemia risk in a Tunisian population.
|
25311495 |
2015 |
|
rs3822214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other genetic changes were found in 15 of 57 samples with AML: polymorphisms Met541Leu in 14% of cases, Lys546Lys in 7% and 1 case of acute biclonal leukemia, Ile798Ile in 5.3% of cases, Met541Leu in 1 acute biphenotypic leukemia and in 6.3% of ALL.
|
25247397 |
2015 |
|
rs387906666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The penetrance of the CBL Y371C mutation was 30% for JMML and 40% for all leukemia.
|
25939664 |
2015 |
|
rs387907272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significance of MYD88 L265P Mutation Status in the Subclassification of Low-Grade B-Cell Lymphoma/Leukemia.
|
26230596 |
2015 |
|
rs104894230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D) mutation and AML1/ETO fusion protein.
|
24480914 |
2014 |
|
rs10931910
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant decrease in clearance (τ=-0.32, P=0.003) in solid tumor patients with rs10931910, although it failed to replicate in the leukemia cohort (τ=0.18, P=0.20).
|
24300566 |
2014 |
|
rs121913227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a patient with a BRAF(V600K)-mutant melanoma responding to vemurafenib, we observed accelerated progression of a previously unrecognized NRAS-mutant leukemia.
|
24589925 |
2014 |
|
rs121913237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a multiplexed analysis of RAS-dependent signaling, Mac-1(Low) cells, which harbor leukemia stem cells, were preferentially sensitive to NRAS(G12V) withdrawal.
|
25316678 |
2014 |
|
rs1482518887
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D) mutation and AML1/ETO fusion protein.
|
24480914 |
2014 |
|
rs1801394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that MTRR A66G GG is associated with decreased risk of leukemia in a Caucasian population and in children, especially for ALL.
|
24261678 |
2014 |
|
rs1979277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk.
|
24716966 |
2014 |