rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.
|
29788924 |
2018 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role in mortality of patients has not been established.
|
26490305 |
2016 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among Europeans, we found that the two SNPs previously reported at 9q22 were not independently associated to DTC and that rs965513 was the predominant signal; at 14q13, we showed that the haplotype rs944289[C]-rs116909374[C]-rs999460[T] was significantly associated with DTC risk and that the association with rs116909374 differed by smoking status (p-interaction = 0.03).
|
26991144 |
2016 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Furthermore, DTC risk was positively associated with the number of copies in the minor allele (A) of rs965513 among people who consumed less iodine than the median.
|
27610545 |
2016 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
For the GWAS SNP rs965513 near FOXE1, an association was found between genotypes G/A and A/A, and risk of DTC.
|
25849217 |
2015 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
|
25879635 |
2015 |
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our results confirm that the FOXE1 rs965513 SNP confers an increased risk for DTC in the German population, particularly allele "A" and the genotypes "AA" and "AG" for PTC.
|
24325646 |
2014 |