|
rs2472299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs2472299 in CYP1A2 gene showed suggestive association with reduced risk of DCM in the dominant model (P<sub>a</sub> = 4.24 × 10<sup>-2</sup> ) and was correlated with smoking status in patients with DCM (P<sub>a</sub> = 1.56 × 10<sup>-2</sup> ).
|
29577422 |
2018 |
|
rs2505568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of five haplotypes constructed, TAC (rs61330082-rs2505568-rs9034) was a protective haplotype to DCM (OR: 0.22, 95% CI = 0.13-0.39, p = 1.84 × 10(-8)).
|
26389889 |
2015 |
|
rs118204016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ACADVL R450H mutation is an uncommon cause of the DCM phenotype that appears to be autosomal recessive.
|
30840296 |
2019 |
|
rs1267969615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results indicate that the ACE I/D and angiotensinogen M235T and T174M polymorphisms are not related to HCM or DCM in the Japanese population, and that variants of these polymorphisms do not contribute to the genesis or progression of these cardiomyopathies.
|
9270088 |
1997 |
|
rs1267969615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
|
rs145579007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated whether the Arg16Gly and Gln27Glu variants of the beta2-AR gene predict left ventricular ejection fraction (LVEF) and LV end diastolic diameter (LVEDD) in patients with idiopathic dilated cardiomyopathy (IDC) before and 6 months after receiving standard medical therapy other than beta-AR blockers.
|
17117186 |
2007 |
|
rs750712925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated whether the Arg16Gly and Gln27Glu variants of the beta2-AR gene predict left ventricular ejection fraction (LVEF) and LV end diastolic diameter (LVEDD) in patients with idiopathic dilated cardiomyopathy (IDC) before and 6 months after receiving standard medical therapy other than beta-AR blockers.
|
17117186 |
2007 |
|
rs670957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the potential role of these three genes in DCM, we examined 11 single nucleotide polymorphisms (SNPs) in the ZBTB17, HSPB7 and ACTC1 genes: namely, rs10927875 in ZBTB17; rs1739843, rs7523558, and rs6660685 in HSPB7; rs533021, rs589759, rs1370154, rs2070664, rs3759834, rs525720 and rs670957 in ACTC1.
|
23570452 |
2013 |
|
rs1801252
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further, significantly elevated IDCM risk was associated with Ser49Gly polymorphisms for all genetic models.
|
21553224 |
2012 |
|
rs1801252
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotyping at 3 loci (ADRB1 Ser49Gly and Arg389Gly, and NET T-182C) was performed in 83 patients with DCM.
|
22664639 |
2012 |
|
rs1801253
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotyping at 3 loci (ADRB1 Ser49Gly and Arg389Gly, and NET T-182C) was performed in 83 patients with DCM.
|
22664639 |
2012 |
|
rs1801253
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the genesis, progression, or arrhythmogenesis of dilated cardiomyopathy (DCM).
|
12197595 |
2002 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results indicate that the ACE I/D and angiotensinogen M235T and T174M polymorphisms are not related to HCM or DCM in the Japanese population, and that variants of these polymorphisms do not contribute to the genesis or progression of these cardiomyopathies.
|
9270088 |
1997 |
|
rs4762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results indicate that the ACE I/D and angiotensinogen M235T and T174M polymorphisms are not related to HCM or DCM in the Japanese population, and that variants of these polymorphisms do not contribute to the genesis or progression of these cardiomyopathies.
|
9270088 |
1997 |
|
rs755661906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three missense heterozygous ANKRD1 mutations (P105S, V107L, and M184I) were identified in 4 DCM patients.
|
19608030 |
2009 |
|
rs755559514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We prospectively evaluated 202 consecutive patients with IDC and 202 matched controls: 90 were screened for APJ gene mutations and all 202 were genotyped for G212A and A445C APJ receptor polymorphisms.
|
17826642 |
2007 |
|
rs2781666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The serum lipids were quantified using spectrophotometric assay, serum arginase activity was done by enzyme colorimetric assay and 2 polymorphisms (rs2781666 and rs2781667) in ARG1 were typed by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) to find out disease associate allele/haplotype segregating in subjects affected by IDCM.Significantly high arginase activity was found to be associated with IDCM subjects when compared with population-matched healthy controls (P < .0001).
|
31764771 |
2019 |
|
rs2781666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype TT at rs2781666G/T and rs2781667C/T also showed a significantly association (P < .0001).To our knowledge, this is the first report to show a significant involvement of ARG1 polymorphisms to produce IDCM symptoms in subjects originating in Pakistan.
|
31764771 |
2019 |
|
rs2781667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The serum lipids were quantified using spectrophotometric assay, serum arginase activity was done by enzyme colorimetric assay and 2 polymorphisms (rs2781666 and rs2781667) in ARG1 were typed by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) to find out disease associate allele/haplotype segregating in subjects affected by IDCM.Significantly high arginase activity was found to be associated with IDCM subjects when compared with population-matched healthy controls (P < .0001).
|
31764771 |
2019 |
|
rs2781667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype TT at rs2781666G/T and rs2781667C/T also showed a significantly association (P < .0001).To our knowledge, this is the first report to show a significant involvement of ARG1 polymorphisms to produce IDCM symptoms in subjects originating in Pakistan.
|
31764771 |
2019 |
|
rs12921862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AA/AC and AC genotypes of rs12921862</span> in the dominant and the overdominant genetic models also presented a correlation with poor prognosis of DCM in both univariate (<i>p</i> < 0.01) and multivariate analyses (<i>p</i> < 0.01) after adjusting for age, gender, left ventricular (LV) end-diastolic diameter, and LV ejection fraction.
|
30810360 |
2019 |
|
rs1805105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypic frequencies of rs12921862 and rs1805105 were associated with the susceptibility of DCM in codominant, dominant, and overdominant models (<i>p</i> < 0.01).
|
30810360 |
2019 |
|
rs2234962
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three DCM-associated SNPs were confirmed by individual genotyping (P < 5.0 10(-7)), and two of them, rs10927875 and rs2234962, were replicated in independent samples (1165 DCM patients and 1302 controls), with P-values of 0.002 and 0.009, respectively. rs10927875 maps to a region on chromosome 1p36.13 which encompasses several genes among which HSPB7 has been formerly suggested to be implicated in DCM.
|
21459883 |
2011 |
|
rs387906876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using isogenic genome-edited human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), we examined how a DCM-causing BAG3 mutation (R477H), as well as complete loss of BAG3 (KO), impacts myofibrillar organization and chaperone networks.
|
31723063 |
2019 |