|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of the G allele at rs10490924 in the ARMS2 gene is likely associated with a lower chance of retreatment after IVA+PDT in patients with PCV.
|
31376050 |
2019 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with GA were significantly older, with a higher prevalence of reticular pseudodrusen, bilateral involvement of advanced AMD and T-allele frequency of ARMS2 A69S compared with those with typical AMD and PCV; although there were no differences in the genetic and clinical characteristics among patients with GA and RAP.
|
26918864 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Subfoveal choroidal thickness and CVH in eyes with treatment-naive polypoidal choroidal vasculopathy were associated with ARMS2 A69S (rs10490924) and CFH (rs1329428).
|
26745149 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Development of PCV in the unaffected fellow eye is associated with ARMS2 A69S genotype in patients with unilateral PCV.
|
26332911 |
2016 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular AMD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011).
|
24865191 |
2014 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with nAMD and PCV (p<0.001).
|
23326481 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations.
|
23697955 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The minor allele frequency (MAF) of rs10490924 was significantly different between Type 1 PCV (n = 81) and control (p < 0.0001), while no difference was found between Type 2 PCV (n = 94) and control (p = 0.20).
|
23289808 |
2013 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are significantly associated with the risk of PCV in a Korean population.
|
21959923 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis showed consistent allelic associations of rs10490924 and rs11200638 with PCV in different study populations.
|
22491416 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
LOC387715 rs10490924 was associated with PCV and its clinical manifestations, and showed a discrepant distribution between PCV and AMD.
|
22509112 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies.
|
23315805 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis provides substantial evidence that the ARMS2 A69S variant confers a significantly higher risk of neovascular AMD than PCV.
|
22219653 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotyping of ARMS2 A69S is more informative than that of CFH I62V in understanding the clinical features in patients with PCV.
|
21397333 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the multivariate regression analysis, the additive model of the G allele at rs10490924</span> was associated with a significantly better BCVA 12 months after the first PDT in tAMD and PCV patients.
|
21541271 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p.Ala69Ser polymorphism of the ARMS2 gene is strongly associated with exudative AMD and PCV and is associated marginally with dry AMD.
|
21236409 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Severe vision-threatening complications (ie, suprachoroidal hemorrhage, vitreous hemorrhage, and tears of the retinal pigment epithelium) were seen only in eyes with larger PCV, and in studying single nucleotide polymorphisms A69S of ARMS2 genes, there was a significant difference in T allele frequency between individuals with smaller PCV and those with larger PCV (20.2% vs 79.8%; P = .0235).
|
21457926 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, the distributions of rs10490924 did not differ between the typical PCV and control groups.
|
21896867 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four AMD-associated haplotype-tagging alleles (rs547154, rs1061170, rs1410996, rs10490924) in the 3 major loci, CFH, CFB/C2, and ARMS2/HTRA1, also were statistically significantly associated with the PCV phenotype (P<0.05).
|
20378180 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms responsible for nAMD and PCV may be located in this region or in the strong linkage disequilibrium of rs10490924 and rs11200638.
|
21191724 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ARMS2 A69S has a strong association with all three subtypes, with the association being strongest for RAP and weakest for PCV.
|
20574013 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The LOC387715 A69S genotype is not associated with lesion composition or size on indocyanine green angiography but with lesion size on fluorescein angiography in patients with subfoveal polypoidal choroidal vasculopathy.
|
19898184 |
2009 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs11200638 and TT genotype of rs10490924 conferred a 4.9-fold (95% CI: 1.85-12.95) and 4.89-fold (95% CI: 1.85-12.90) increased risk of PCV, respectively, after adjustment for age and sex.
|
18515590 |
2008 |