|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although our findings were not as robust as the previous studies, they suggest that rs1861972 may influence the risk for autism spectrum disorders.
|
17948868 |
2008 |
|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Here, we have investigated the association of five markers [rs3735653 (C/T) in exon 1; rs34808376 (GC/-) and rs6150410 (CGCATCCCC/-) in promoter region; rs1861972 (A/G) and rs1861973 (C/T) in the intron] of the gene with autism and ASD in Indian population using family-based approach.
|
20050924 |
2010 |
|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Previously we demonstrated that an intronic haplotype (rs1861972-rs1861973 A-C) in the homeobox transcription factor ENGRAILED2 (EN2) is significantly associated with ASD.
|
22180456 |
2012 |
|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD).
|
16252243 |
2005 |
|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This analysis was then extended to include 167 small nuclear ASD pedigrees and significant association was again only observed for rs1861972 and rs1861973 under both the narrow and broad diagnostic criteria (narrow: rs1861972 P=0.0290, rs1861973 P=0.0073, haplotype P=0.0009; broad: rs1861972 P=0.0175, rs1861973 P=0.0107, haplotype P=0.0024).
|
15024396 |
2004 |
|
rs1861972
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Subsequent molecular analysis determined that the EN2 ASD-associated haplotype (rs1861972-rs1861973 A-C) functions as a transcriptional activator to increase gene expression.
|
24520327 |
2014 |
|
rs1861973
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD).
|
16252243 |
2005 |
|
rs1861973
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously we demonstrated that an intronic haplotype (rs1861972-rs1861973 A-C) in the homeobox transcription factor ENGRAILED2 (EN2) is significantly associated with ASD.
|
22180456 |
2012 |
|
rs1861973
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Subsequent molecular analysis determined that the EN2 ASD-associated haplotype (rs1861972-rs1861973 A-C) functions as a transcriptional activator to increase gene expression.
|
24520327 |
2014 |
|
rs1861973
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Here, we have investigated the association of five markers [rs3735653 (C/T) in exon 1; rs34808376 (GC/-) and rs6150410 (CGCATCCCC/-) in promoter region; rs1861972 (A/G) and rs1861973 (C/T) in the intron] of the gene with autism and ASD in Indian population using family-based approach.
|
20050924 |
2010 |
|
rs3735653
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we have investigated the association of five markers [rs3735653 (C/T) in exon 1; rs34808376 (GC/-) and rs6150410 (CGCATCCCC/-) in promoter region; rs1861972 (A/G) and rs1861973 (C/T) in the intron] of the gene with autism and ASD in Indian population using family-based approach.
|
20050924 |
2010 |
|
rs3735653
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate EN2 for evidence of association with ASD, four single-nucleotide polymorphisms (SNPs) (rs3735653, rs1861972, rs1861973, rs2361689) that span the majority of the 8.0 kb gene were assessed by the transmission/disequilibrium test.
|
15024396 |
2004 |
|
rs1026306398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study showed that the G allele of c.425C>G was significantly associated with ASD (Fisher's exact test, P=0.0359).
|
27755371 |
2016 |
|
rs2361689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate EN2 for evidence of association with ASD, four single-nucleotide polymorphisms (SNPs) (rs3735653, rs1861972, rs1861973, rs2361689) that span the majority of the 8.0 kb gene were assessed by the transmission/disequilibrium test.
|
15024396 |
2004 |