|
rs2596542
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
|
rs2596542
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele in MICA rs2596542 is a protective factor for hepatocarcinogenesis, whereas the T allele is a risk factor.
|
30882647 |
2019 |
|
rs28934571
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, an arginine to serine mutation at codon 249 of the p53 tumor suppressor gene is produced, abrogating the function of the tumor suppressor gene, and contributing to hepatocarcinogenesis.
|
24078988 |
2013 |
|
rs28934571
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC.
|
20538734 |
2010 |
|
rs246871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that PD1 rs41386349 and rs6710479 and TIM3 rs246871 and interactions between PD1 and TIM3 polymorphisms may affect the susceptibility of chronic HBV infection and PD1 rs2227982, rs6710479, and rs7421861 may implicate in hepatocarcinogenesis.
|
30939292 |
2019 |
|
rs3821204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that ST2 rs3821204 CC genotype may contribute to hepatocarcinogenesis by enhancing ST2 production at the transcriptional and translational level.
|
29656959 |
2019 |
|
rs41386349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that PD1 rs41386349 and rs6710479 and TIM3 rs246871 and interactions between PD1 and TIM3 polymorphisms may affect the susceptibility of chronic HBV infection and PD1 rs2227982, rs6710479, and rs7421861 may implicate in hepatocarcinogenesis.
|
30939292 |
2019 |
|
rs6710479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that PD1 rs41386349 and rs6710479 and TIM3 rs246871 and interactions between PD1 and TIM3 polymorphisms may affect the susceptibility of chronic HBV infection and PD1 rs2227982, rs6710479, and rs7421861 may implicate in hepatocarcinogenesis.
|
30939292 |
2019 |
|
rs7421861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that PD1 rs41386349 and rs6710479 and TIM3 rs246871 and interactions between PD1 and TIM3 polymorphisms may affect the susceptibility of chronic HBV infection and PD1 rs2227982, rs6710479, and rs7421861 may implicate in hepatocarcinogenesis.
|
30939292 |
2019 |
|
rs12979860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the current study did not find a significant association between IL28B rs12979860 polymorphism and hepatocarcinogenesis.
|
27083168 |
2017 |
|
rs1367492395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines.
|
26706415 |
2016 |
|
rs867384693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR.
|
27167190 |
2016 |
|
rs145204276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our findings provided evidence that rs145204276 may contribute to hepatocarcinogenesis by affecting methylation status of the GAS5 promoter and subsequently its transcriptional activity thus serving as a potential therapy target for HCC.
|
26163879 |
2015 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
|
26150517 |
2015 |
|
rs11134527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs11134527 may be a novel genetic risk factor of HCC in HBV-exposed subjects, can facilitate HBV preS deletion generation and predispose the host to the effect of T1674C/G and preS1 start codon mutation in hepatocarcinogenesis.
|
24118778 |
2014 |
|
rs56228771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, we provided initial evidence that rs56228771 may contribute to hepatocarcinogenesis, possibly by affecting SGSM3 expression through a miRNA-mediated regulation.
|
23918301 |
2014 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
rs391957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings provided new insights into the pathogenesis of HCC and an unexpected effect of the interaction between rs391957 and Ets-2 on hepatocarcinogenesis, and especially supported the hypothesis that stress-related and evolutionarily conserved genetic variant(s) influencing transcriptional regulation could predict susceptibilities.
|
23416888 |
2013 |
|
rs897092263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, an arginine to serine mutation at codon 249 of the p53 tumor suppressor gene is produced, abrogating the function of the tumor suppressor gene, and contributing to hepatocarcinogenesis.
|
24078988 |
2013 |
|
rs1049606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included novel SNPs for hepatocarcinogenesis with HCV CCND2 rs1049606, RAD23B rs1805329, CEP164 rs573455, and GRP78rs430397 in addition to the known SNPs MDM2 rs2279744 and ALDH2 rs671.
|
22004425 |
2012 |
|
rs10680577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our findings provided strong evidence for the hypothesis that rs10680577 contributes to hepatocarcinogenesis, possibly by affecting RERT-lncRNA structure and subsequently EGLN2 expression, making it a promising biomarker for early diagnosis of HCC.
|
23026137 |
2012 |
|
rs3859501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further studies into the roles of rs3859501 and pri-miRNAs-371-373_ht2 haplotype in hepatocarcinogenesis are needed.
|
22848681 |
2012 |
|
rs4149963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our result demonstrates for the first time that the Exo 1 T439M polymorphism does not have a major role in genetic susceptibility to hepatocarcinogenesis, at least in the population studied here.
|
22296401 |
2011 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.
|
17085873 |
2006 |
|
rs3732379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional independent studies in HCC patients with different ethnic background will be needed to confirm the present study and to elucidate the functional role of CX3CR1 and its polymorphism V249I in chronic liver disease and hepatocarcinogenesis.
|
15809764 |
2005 |