Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10079250
rs10079250
0.010 GeneticVariation BEFREE On contrast, CSF-1 induced a prominent phosphorylation and rapid endocytosis of CSF-1R, leading to an M2-like dominant polarization in macrophages with <i>CSF1R</i> c.1085 genotype A_A, in which CSF-1R inhibitors of PLX3397, BLZ945, and GW2580 inhibited macrophage survival with IC<sub>50</sub> of 10 to 100 nmol/L range.<b>Conclusions:</b> The <i>CSF1R</i> c.1085A>G genetic variant regulates tumor immunity by altering the polarization and function of macrophages. 28724665

2017