Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9332739
rs9332739
C2 ; CYP21A2 ; C2-AS1
0.710 GeneticVariation BEFREE CNV-GA patients had no protective alleles at SNP rs9332739 (C2), compared with GA (27%) and CNV only (10%). 22699975

2012
dbSNP: rs11200638
rs11200638
HTRA1 ; LOC105378525
0.040 GeneticVariation BEFREE Comparing combined CNV-GA to GA and CNV only, patients with both had a higher frequency of at-risk alleles at both SNPs within the HTRA1 gene-rs10490924 (52.5%), rs11200638 (52.6%). 22699975

2012
dbSNP: rs10490924
rs10490924
ARMS2 ; LOC105378525
0.800 GeneticVariation BEFREE Although genetic markers were associated significantly with 3-year CNV (CFH: Y402H; ARMS2: A69S) and GA incidence (CFH: Y402H), the inclusion of genetic factors in the models provided only marginal improvements in predictive performance. 22704140

2012
dbSNP: rs1061170
rs1061170
CFH
0.760 GeneticVariation BEFREE Although genetic markers were associated significantly with 3-year CNV (CFH: Y402H; ARMS2: A69S) and GA incidence (CFH: Y402H), the inclusion of genetic factors in the models provided only marginal improvements in predictive performance. 22704140

2012
dbSNP: rs10490924
rs10490924
ARMS2 ; LOC105378525
T 0.800 GeneticVariation GWASCAT In the analysis comparing participants with CNV to those with GA, a statistically significant association was observed at the ARMS2/HTRA1 locus (rs10490924; odds ratio [OR], 1.47; P = 4.3 × 10(-9)), which was confirmed in the replication samples (OR, 1.38; P = 7.4 × 10(-14) for combined discovery and replication analysis). 22705344

2012
dbSNP: rs1061170
rs1061170
CFH
0.760 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs2230199
rs2230199
C3
C 0.720 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs1789110
rs1789110 		0.710 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs2842992
rs2842992 		0.710 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs641153
rs641153
CFB ; CYP21A2
0.710 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs9332739
rs9332739
C2 ; CYP21A2 ; C2-AS1
0.710 GeneticVariation GWASCAT Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs3732378
rs3732378
CX3CR1
0.010 GeneticVariation BEFREE Subjects with AMD Grades 0-1 (n = 188) were compared to those with AMD Grades 2-3 (n = 138), to those with AMD Grade 4 (geographic atrophy) (n = 20) and to those with AMD Grade 5 (neovascular AMD) (n = 25) with regard to the presence of CX3CR1 polymorphisms (V249I and T280M). 22816662

2012
dbSNP: rs3732379
rs3732379
CX3CR1
0.010 GeneticVariation BEFREE In this Greek population, after adjusting for known risk factors, increased risk of geographic atrophy (GA) AMD among the carriers of the V249I polymorphism in the CX3CR1 gene was found. 22816662

2012
dbSNP: rs9621532
rs9621532
SYN3
0.010 GeneticVariation BEFREE Polychotomous logistic regression showed a trend that rs9621532 correlates with less severe disease, for example, with the majority of carriers having intermediate AMD rather than nAMD/geographic atrophy AMD. 23422939

2013
dbSNP: rs1789110
rs1789110 		0.710 GeneticVariation BEFREE A recent genome-wide association study has reported three newly identified susceptible loci (rs2842992 near the gene SOD2, rs1789110 near the gene MBP and rs722782 near the gene C8orf42) to be associated with the geographic atrophy subtype of age-related macular degeneration in European-descent population. 24667176

2014
dbSNP: rs2842992
rs2842992 		0.710 GeneticVariation BEFREE A recent genome-wide association study has reported three newly identified susceptible loci (rs2842992 near the gene SOD2, rs1789110 near the gene MBP and rs722782 near the gene C8orf42) to be associated with the geographic atrophy subtype of age-related macular degeneration in European-descent population. 24667176

2014
dbSNP: rs722782
rs722782 		0.010 GeneticVariation BEFREE A recent genome-wide association study has reported three newly identified susceptible loci (rs2842992 near the gene SOD2, rs1789110 near the gene MBP and rs722782 near the gene C8orf42) to be associated with the geographic atrophy subtype of age-related macular degeneration in European-descent population. 24667176

2014
dbSNP: rs10490924
rs10490924
ARMS2 ; LOC105378525
0.800 GeneticVariation BEFREE Analyzing the currently largest dataset on GA lesion growth (N = 388), our findings suggest a significant and independent contribution of three factors on GA lesion growth including at least two genetic factors (ARMS2_rs10490924 [P < 0.00088] and C3_rs2230199 [P < 0.00015]) as well as one clinical component (presence of GA in the fellow eye [P < 0.00023]). 25962167

2015
dbSNP: rs2230199
rs2230199
C3
0.720 GeneticVariation BEFREE Analyzing the currently largest dataset on GA lesion growth (N = 388), our findings suggest a significant and independent contribution of three factors on GA lesion growth including at least two genetic factors (ARMS2_rs10490924 [P < 0.00088] and C3_rs2230199 [P < 0.00015]) as well as one clinical component (presence of GA in the fellow eye [P < 0.00023]). 25962167

2015
dbSNP: rs2230199
rs2230199
C3
0.720 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016
dbSNP: rs142450006
rs142450006 		0.710 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016
dbSNP: rs10033900
rs10033900
CFI
0.700 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016
dbSNP: rs10781182
rs10781182 		0.700 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016
dbSNP: rs10922109
rs10922109
CFH
0.700 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016
dbSNP: rs11080055
rs11080055
TMEM97
0.700 GeneticVariation GWASCAT A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988

2016