SNPs Met235Thr in angiotensinogen, T>C (-344) in aldosterone synthase, and G>A (-1903) in chymase genes are significantly associated with diabetic chronic renal insufficiency in Indian patients and warrant replication in larger sample sets.
Three variants returned significant results in populations with different ethnicities at p<0.05: <i>ACE</i> insertion, <i>AGT</i> rs699-T allele and <i>AGTR1</i> rs5186-A allele; each variant was associated with a reduced risk of CKD development.
Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609-0.965).