Three variants returned significant results in populations with different ethnicities at p<0.05: <i>ACE</i> insertion, <i>AGT</i> rs699-T allele and <i>AGTR1</i> rs5186-A allele; each variant was associated with a reduced risk of CKD development.
The angiotensin II Type 1 receptor (AT1R) A1166C (rs5186) genez polymorphism is equivocally associated with the patients' susceptibility to chronic kidney disease or end-stage renal disease.