Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients. 23846111

2013

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH. 23534584

2013

dbSNP: rs1800471
rs1800471
0.020 GeneticVariation BEFREE To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --> Pro) and codon 25 (Arg(25) --> Pro). 11008076

2000

dbSNP: rs1800471
rs1800471
0.020 GeneticVariation BEFREE Secondly, we performed a case-control orientated study to determine whether rs1800471 polymorphism and other factors influence the progression of renal impairment. 25298263

2015

dbSNP: rs28933979
rs28933979
TTR
0.020 GeneticVariation BEFREE Renal manifestations of ATTR V30M, like other amyloidoses, are different levels of proteinuria and renal insufficiency. 12832749

2003

dbSNP: rs28933979
rs28933979
TTR
0.020 GeneticVariation BEFREE ATTR-V30M patients with FNEs had longer disease duration (OR=1.24; 95% CI 1.07 to 1.43), renal dysfunction (OR=4.65; 95% CI 1.20 to 18.05) and were men (OR=3.57; 95% CI 1.02 to 12.30). 25091367

2015

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We analyzed single nucleotide polymorphisms (SNPs) associated with cardiovascular pathophysiology (including AGT1R T573C, AGT1R A1166C, and AGT M235T) and presence of renal dysfunction (eGFR<60 ml/min/1.73 m2) or history of CHD. 19327134

2009

dbSNP: rs1128503
rs1128503
0.010 GeneticVariation BEFREE In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities. 20030680

2011

dbSNP: rs12026
rs12026
0.010 GeneticVariation BEFREE We examined the relationship between variation at the C311S and A148G polymorphisms (together with PON2 intronic variant rs12704795) and indices of renal dysfunction (progression to micro- and macroalbuminuria, plasma creatinine increases) in 3,374 newly diagnosed type 2 diabetic subjects from the UK Prospective Diabetes Study followed prospectively (median 14.0 years), using proportional hazards models, adjusted for sex, ethnicity and other known or putative risk factors. 17096118

2006

dbSNP: rs121918079
rs121918079
TTR
0.010 GeneticVariation BEFREE This case illustrated the clinical and pathologic phenotype of an ATTR amyloidosis patient who initially presented impaired renal function and p.Leu75Pro variant was found by sequencing the coding region of TTR gene. 28272196

2017

dbSNP: rs1267969615
rs1267969615
ACE
0.010 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003

dbSNP: rs12704795
rs12704795
0.010 GeneticVariation BEFREE We examined the relationship between variation at the C311S and A148G polymorphisms (together with PON2 intronic variant rs12704795) and indices of renal dysfunction (progression to micro- and macroalbuminuria, plasma creatinine increases) in 3,374 newly diagnosed type 2 diabetic subjects from the UK Prospective Diabetes Study followed prospectively (median 14.0 years), using proportional hazards models, adjusted for sex, ethnicity and other known or putative risk factors. 17096118

2006

dbSNP: rs1382048442
rs1382048442
0.010 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013

dbSNP: rs138207257
rs138207257
0.010 GeneticVariation BEFREE The p.Pro190Leu mutation was reported with impaired renal function at follow-up; however, the p.Gly287Val was presented with normal renal function. 27561601

2017

dbSNP: rs1617640
rs1617640
EPO
0.010 GeneticVariation BEFREE Our analysis suggests that the risk allele (T) of rs1617640 plays a role in the development of renal dysfunction after cardiac surgery with CPB. 21092038

2010

dbSNP: rs17319721
rs17319721
0.010 GeneticVariation BEFREE Covariate adjustment analysis showed that the variant at rs17319721 in SHROOM3 was an independent risk factor for renal dysfunction after the first month after transplantation (P=0.022). 27779570

2017

dbSNP: rs1800470
rs1800470
0.010 GeneticVariation BEFREE To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --> Pro) and codon 25 (Arg(25) --> Pro). 11008076

2000

dbSNP: rs188942711
rs188942711
0.010 GeneticVariation BEFREE The early demonstration of R229Q in individuals with TBMN may indicate those at increased risk of proteinuria and renal impairment. 18726620

2008

dbSNP: rs202047589
rs202047589
0.010 GeneticVariation BEFREE The p.Pro190Leu mutation was reported with impaired renal function at follow-up; however, the p.Gly287Val was presented with normal renal function. 27561601

2017

dbSNP: rs281874657
rs281874657
0.010 GeneticVariation BEFREE The index case had the p.Q379X variant in COL4A5 and currently had renal impairment, (eGFR = 45 ml/min/1.73 m<sup>2</sup>), bilateral hearing loss, and central and peripheral retinopathies. 27485810

2017

dbSNP: rs34557412
rs34557412
0.010 GeneticVariation BEFREE We report the case of a man with CVID in association with a heterozygous TACI gene mutation (C104R) who had a highly unusual, invasive, polyclonal CD8+ T-cell lymphoproliferation resulting in massive hepatosplenomegaly and causing renal impairment because of infiltration. 16630947

2006

dbSNP: rs367825197
rs367825197
0.010 GeneticVariation BEFREE In the present study, we report the identification of a heterozygous nonsense <i>PODXL</i> mutation (c.C976T; p. Arg326X) in a Chinese pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES). 30523047

2019