Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1128503
rs1128503
0.010 GeneticVariation BEFREE In the CsA patient group (n = 30), age (p = 0.008), hypertension (p = 0.017), renal dysfunction (p < 0.001), ABCB1 C1236T (p < 0.001), and G2677T/A (p = 0.014) were associated with neurotoxicities. 20030680

2011

dbSNP: rs1382048442
rs1382048442
0.010 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013

dbSNP: rs1267969615
rs1267969615
ACE
0.010 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003

dbSNP: rs538166970
rs538166970
ACE
0.010 GeneticVariation BEFREE In contrast, another mutant, R1180P, was compatible with life after transient neonatal renal insufficiency. 24163131

2014

dbSNP: rs867394500
rs867394500
ACE
0.010 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We analyzed single nucleotide polymorphisms (SNPs) associated with cardiovascular pathophysiology (including AGT1R T573C, AGT1R A1166C, and AGT M235T) and presence of renal dysfunction (eGFR<60 ml/min/1.73 m2) or history of CHD. 19327134

2009

dbSNP: rs74315289
rs74315289
0.010 GeneticVariation BEFREE Renal dysfunction and barttin expression in Bartter syndrome Type IV associated with a G47R mutation in BSND in a family. 21269598

2011

dbSNP: rs777919630
rs777919630
CBS
0.010 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001

dbSNP: rs137852832
rs137852832
A 0.700 CausalMutation CLINVAR

dbSNP: rs137852834
rs137852834
A 0.700 CausalMutation CLINVAR

dbSNP: rs771454167
rs771454167
A 0.700 CausalMutation CLINVAR

dbSNP: rs188942711
rs188942711
0.010 GeneticVariation BEFREE The early demonstration of R229Q in individuals with TBMN may indicate those at increased risk of proteinuria and renal impairment. 18726620

2008

dbSNP: rs1569492161
rs1569492161
C 0.700 CausalMutation CLINVAR

dbSNP: rs281874657
rs281874657
0.010 GeneticVariation BEFREE The index case had the p.Q379X variant in COL4A5 and currently had renal impairment, (eGFR = 45 ml/min/1.73 m<sup>2</sup>), bilateral hearing loss, and central and peripheral retinopathies. 27485810

2017

dbSNP: rs1617640
rs1617640
EPO
0.010 GeneticVariation BEFREE Our analysis suggests that the risk allele (T) of rs1617640 plays a role in the development of renal dysfunction after cardiac surgery with CPB. 21092038

2010

dbSNP: rs696217
rs696217
0.010 GeneticVariation BEFREE The Leu72Met polymorphism was also associated with serum total cholesterol levels in diabetic nephropathy patients with renal</span> dysfunction; the 72Met carriers had lower total cholesterol levels than the 72Met non-carriers (P < 0.05). 16793966

2006

dbSNP: rs7456421
rs7456421
0.010 GeneticVariation BEFREE No statistical significance of allele transfer was found, which means that there were no associations between rs7456421 and rs 2030712 SNPs of HIPK2 gene and the incidence of renal dysfunction. 23540226

2013

dbSNP: rs138207257
rs138207257
0.010 GeneticVariation BEFREE The p.Pro190Leu mutation was reported with impaired renal function at follow-up; however, the p.Gly287Val was presented with normal renal function. 27561601

2017

dbSNP: rs202047589
rs202047589
0.010 GeneticVariation BEFREE The p.Pro190Leu mutation was reported with impaired renal function at follow-up; however, the p.Gly287Val was presented with normal renal function. 27561601

2017

dbSNP: rs530391015
rs530391015
A 0.700 GeneticVariation CLINVAR

dbSNP: rs7222094
rs7222094
0.010 GeneticVariation BEFREE Patients having the CC genotype of rs7222094 in SPH experienced more renal and hematological dysfunction (p = 0.003 and p = 0.011), while patients of the VASST cohort with the rs7222094 CC genotype showed the same trend toward more renal dysfunction. 21257964

2011

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients. 23846111

2013

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001