|
rs1161136341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1<sup>R132H</sup>) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor.
|
31151327 |
2019 |
|
rs121918464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the effects of gain-of-function (GOF) E76K-mutant Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) on the biological behaviors of glioblastoma (GBM) cells, and explore the molecular mechanisms of GBM progression.
|
31807022 |
2019 |
|
rs1249080185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the effects of gain-of-function (GOF) E76K-mutant Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) on the biological behaviors of glioblastoma (GBM) cells, and explore the molecular mechanisms of GBM progression.
|
31807022 |
2019 |
|
rs12885300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs of DIO1 gene (rs2235544) and DIO2 gene (rs12885300) have independent prognostic significance in glioblastoma patients.
|
31452060 |
2019 |
|
rs144551722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs144551722 SNP was a significant predictor of development of glioblastoma in males (p-value = 0.0056) but not in females even after correction for multiple testing.
|
31556016 |
2019 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It seems that polymorphism of T29C (L10P, rs1982073, or rs1800470), which has been studied in various cancers such as breast and colon, creates the significant differences plays an important role in GBM prognosis and treatment.
|
31160907 |
2019 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of rs1982073 polymorphism of transforming growth factor-β1 in glioblastoma.
|
31160907 |
2019 |
|
rs2235544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs of DIO1 gene (rs2235544) and DIO2 gene (rs12885300) have independent prognostic significance in glioblastoma patients.
|
31452060 |
2019 |
|
rs28357681
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma.
|
31323957 |
2019 |
|
rs4644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNP sites (rs4644 and rs4652) across the <i>LGALS3</i> gene were associated with increased risk for glioblastoma, and the C allele of rs4652 and the A allele of rs4644 could enhance glioblastoma resistance to radio-chemotherapy, but not cell proliferation.
|
30341098 |
2019 |
|
rs4652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNP sites (rs4644 and rs4652) across the <i>LGALS3</i> gene were associated with increased risk for glioblastoma, and the C allele of rs4652 and the A allele of rs4644 could enhance glioblastoma resistance to radio-chemotherapy, but not cell proliferation.
|
30341098 |
2019 |
|
rs562015640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the effects of gain-of-function (GOF) E76K-mutant Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) on the biological behaviors of glioblastoma (GBM) cells, and explore the molecular mechanisms of GBM progression.
|
31807022 |
2019 |
|
rs774238794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1<sup>R132H</sup>) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor.
|
31151327 |
2019 |
|
rs1005230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma.
|
29584591 |
2018 |
|
rs1135401891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report on the expression of wild-type and L441P variants of human PO in a U87 glioblastoma human cell line in an attempt to assess their effect on glutamate metabolism.
|
29694413 |
2018 |
|
rs11554137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Clinical prognostic value of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in glioblastoma.
|
29423539 |
2018 |
|
rs11558961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, rs11558961 might influence the chemoresistance and progression of GBM cells via promoting the binding of miR-139, ultimately decrease the susceptibility of GBM.
|
29746255 |
2018 |
|
rs121913343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Biallelic GOF mutations (p.R273H and p.R273C) were identified in a 19-year-old male with glioblastoma (allele frequencies 94% and 48%) and a 54-year-old with pT3 penile squamous cell carcinoma (allele frequencies 19% and 27%).
|
29666004 |
2018 |
|
rs121913444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using next-generation sequencing, array comparative genomic hybridization and droplet digital PCR, we identified the p.L861Q EGFR mutation in a case of GBM for the first time.
|
30305059 |
2018 |
|
rs149840192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Studies have shown p.A289V mutation responding to tyrosine kinase inhibitors (TKIs) in glioblastoma cell lines suggesting the point mutation as a potential therapeutic target.
|
30572543 |
2018 |
|
rs2440472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population.
|
30595704 |
2018 |
|
rs2904551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report on the expression of wild-type and L441P variants of human PO in a U87 glioblastoma human cell line in an attempt to assess their effect on glutamate metabolism.
|
29694413 |
2018 |
|
rs3024994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma.
|
29584591 |
2018 |
|
rs373191257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population.
|
30595704 |
2018 |
|
rs833061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |