Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. 23792957

2013
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. 23847046

2013
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Human DJ-1 and its homologs are novel glyoxalases. 22523093

2012
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. 19229105

2009
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. 17846173

2007
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). 15365989

2004
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. 15254937

2004
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. 14607841

2004
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT The role of pathogenic DJ-1 mutations in Parkinson's disease. 12953260

2003
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. 14713311

2003
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. 12446870

2003
dbSNP: rs774005786
rs774005786
PARK7
0.700 GeneticVariation UNIPROT L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. 12851414

2003