|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
849 CAD patients undergoing revascularization (660 with CAC and 189 without CAC) were enrolled in a cohort study to test its association with cardiovascular events in CAD patients with and without CAC in a 3-year follow-up. rs1333049 was significantly associated with the incidence of cardiovascular events in non-target vessels in patients with CAC (hazard ratio = 1.44, 95%CI, 1.08-1.91, P = 0.012), but not in those without CAC.
|
24732910 |
2014 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
rs10757274
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
rs2891168
|
|
G |
0.820 |
GeneticVariation |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
rs2891168
|
|
|
0.820 |
GeneticVariation |
BEFREE |
A genomic region on chromosome 9p21 has been identified as closely associated with increased susceptibility to coronary artery disease (CAD) and to type 2 diabetes (T2D) although the evidence suggests that the genetic variants within chromosome 9p21 that contribute to CAD are different from those that contribute to T2D.We carried out an association case-control study in an Italian population to test the association between two single nucleotide polymorphisms (SNPs) on the 9p21 locus, rs2891168 and rs10811661, previously reported by the PROCARDIS study, and respectively myocardial infarction (MI) and T2D.
|
20403154 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A replication study and a meta-analysis of the association between the CDKN2A rs1333049 polymorphism and coronary heart disease.
|
24930384 |
2014 |
|
rs10757274
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, rs2383206, rs10757274, and rs10757278 polymorphisms were also significantly correlated with the likelihood of CAD in Caucasians and West Asians.
|
30387168 |
2019 |
|
rs10757274
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allelic variants of the rs10757278 polymorphism functionally affect the activity of the 9p21.3 locus; therefore, we conducted a study to determine whether the rs10757278 is associated with premature CAD in Polish patients.
|
22946666 |
2012 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
|
19548844 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
|
rs10738607
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Among the four variants reaching GWAS significance in the present study, the rs10738607_G [0.78(0.71-0.85); p = 2.17E-08] in CDNK2A/B gene was associated with CAD.
|
26708285 |
2016 |
|
rs10738607
|
|
G |
0.720 |
GeneticVariation |
GWASCAT |
Among the four variants reaching GWAS significance in the present study, the rs10738607_G [0.78(0.71-0.85); p = 2.17E-08] in CDNK2A/B gene was associated with CAD.
|
26708285 |
2016 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of the rs10757278, rs11881940 and rs3803 loci showed that haplotypes ATC (OR = 4.26; 95%CI = 2.85-6.40, P < 0.01), GAC (OR = 1.50; 95%CI = 1.25-1.81, P < 0.01) and GAT (OR = 1.53; 95%CI = 1.12-2.09, P < 0.01) were CAD risk factors, whereas GTC was protective (OR = 0.48; 95%CI = 0.32-0.72, P < 0.01).
|
24782050 |
2014 |
|
rs2891168
|
|
G |
0.820 |
GeneticVariation |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.
|
28639227 |
2017 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CDKN2B gene expression is affected by 9p21.3 rs10757278 in CAD patients, six months after the MI.
|
31386834 |
2019 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040).
|
24777168 |
2014 |
|
rs1333040
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040).
|
24777168 |
2014 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease.
|
21852414 |
2011 |
|
rs10757278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease.
|
18459066 |
2009 |