|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict CAD risk (Odds Ratio [OR] per R allele 0.98[0.84-1.15], p = 0.8).
|
19710913 |
2009 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study.
|
21982484 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics.
|
11375798 |
2001 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis.
|
15214960 |
2004 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis.
|
29952962 |
2018 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the three SNPs, only the R allele of Q192R polymorphism was associated with CAD (p<0.05).
|
22750797 |
2012 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the risk of CAD associated with PON1 Q192R and L55M polymorphisms in 298 CAD patients and 298 healthy individuals.
|
19280995 |
2008 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed two common polymorphisms in PON1 (i.e., M/L55 and R/Q 192 mutations) and PON2 (i.e., G/A148 and C/S311 mutations) in 352 high-risk patients with angiographically defined CAD.
|
14996478 |
2004 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the clinical relevance of the PON1 Q192R genotype in a population of individuals with coronary artery disease who underwent stent implantation and received clopidogrel therapy.
|
21170047 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population.
|
17032132 |
2006 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, our data indicate that the Q/R192 is principally associated with both CAD and ischemic stroke in Japanese.
|
10729395 |
2000 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PON1 Q192R can be used as the DNA marker test to evaluate the risk of CAD in postmenopausal Indian women with high ApoB.
|
23171143 |
2013 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies have been conducted to evaluate the possible "protective" role of PON, and especially the influence of the Arg-->Gln 192 polymorphism, in coronary artery disease.
|
9746266 |
1998 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD.
|
21231776 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease.
|
25155309 |
2016 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was an evaluation of a possible association between R192Q polymorphism of PON1 gene and CAD as well as interactions between polymorphic variants and conventional risk factors of CAD in determining the risk of the disease.
|
17560461 |
2007 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study, thus, identifies the Q192R polymorphism as an additional risk factor for CAD in the Saudi population and suggests that it may have prognostic value.
|
23625196 |
2013 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the Q/R192 polymorphism is not a major risk factor in susceptibility to CAD in the LCAS population.
|
11257264 |
2001 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, PON1 Q192R polymorphism is significantly associated with susceptibility of CAD in the Chinese Han population, and the 192R allele might be an independent predictor for CAD.
|
24918121 |
2014 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results suggest that no association exists between the Gln192Arg polymorphism of paraoxonase and CAD in Turkish patients.
|
10854678 |
2000 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be associated with the risk of CAD in several European or European-derived populations.
|
12454802 |
2003 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease.
|
12618290 |
2003 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study will give an insight about the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM.
|
21438666 |
2011 |
|
rs662
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results suggest that there is an association between the PON 1 L/M 55 polymorphism of paraoxonase and CAD in Turkish patients but not with PON 1 Q/R 192 polymorphism.
|
19226538 |
2009 |