rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In all, 950 patients with early onset CAD (age 56.1 +/- 9.6 years) and an independent sample of 764 patients with late onset CAD (age 70.0 +/- 8.0 years) were enrolled from the cardiac catheterization laboratories at the University of Ottawa Heart Institute from April 15, 2006, to August 15, 2008, and genotyped for the single nucleotide polymorphism rs1333049 9p21 risk variant.Angiographers were blinded to genotype.
|
20670758 |
2010 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population.
|
20691078 |
2010 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
|
19548844 |
2009 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study.
|
19171343 |
2009 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data from two populations show that variant rs1333049 is significantly associated with angiographically characterized CAD.
|
19135198 |
2009 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The meta-analysis of the rs1333049 SNP in 12,0</span>04 cases and 28,949 controls increased the overall level of evidence for association with CAD to P=6.04x10(-10) (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29).
|
18362232 |
2008 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
rs4977574
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
rs4977574
|
|
G |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
|
29263402 |
2017 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
rs4977574
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
rs11556924
|
|
|
0.840 |
GeneticVariation |
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
rs11556924
|
|
T |
0.840 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |