Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined. 20400779

2010

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE In all, 950 patients with early onset CAD (age 56.1 +/- 9.6 years) and an independent sample of 764 patients with late onset CAD (age 70.0 +/- 8.0 years) were enrolled from the cardiac catheterization laboratories at the University of Ottawa Heart Institute from April 15, 2006, to August 15, 2008, and genotyped for the single nucleotide polymorphism rs1333049 9p21 risk variant.Angiographers were blinded to genotype. 20670758

2010

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population. 20691078

2010

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI. 19548844

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study. 19171343

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Our data from two populations show that variant rs1333049 is significantly associated with angiographically characterized CAD. 19135198

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. 18675980

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE The meta-analysis of the rs1333049 SNP in 12,0</span>04 cases and 28,949 controls increased the overall level of evidence for association with CAD to P=6.04x10(-10) (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29). 18362232

2008

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD. 18599798

2008

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). 18264662

2008

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively). 17634449

2007

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population. 30587704

2019

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension. 29791233

2018

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE The rs4977574 with G allele may confer to a higher risk of CAD, especially MI. 30278588

2018

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease. 29894795

2018

dbSNP: rs4977574
rs4977574
A 0.890 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778

2018

dbSNP: rs4977574
rs4977574
G 0.890 GeneticVariation GWASCAT Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. 29263402

2017

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. 25268619

2014

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese. 24804228

2014

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans. 23364394

2013

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study. 23343465

2013

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation BEFREE Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification. 23561647

2013

dbSNP: rs4977574
rs4977574
0.890 GeneticVariation GWASDB Genomewide association analysis of coronary artery disease. 17634449

2007

dbSNP: rs11556924
rs11556924
0.840 GeneticVariation BEFREE In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population. 31679296

2019

dbSNP: rs11556924
rs11556924
T 0.840 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778

2018