|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pooled overall analyses showed that rs1333040 (dominant model: P < 0.0001; recessive model: P < 0.0001; allele model: P < 0.0001), rs1333049 (dominant model: P = 0.02; allele model: P = 0.02) and rs2383207 (additive model: P = 0.004; allele model: P = 0.03) polymorphisms were significantly associated with the likelihood of CAD.
|
30387168 |
2019 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.
|
25333979 |
2015 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population.
|
20691078 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients.
|
21362310 |
2011 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We examined whether genotype at the lead CAD-associated single nucleotide polymorphism (rs1333049) in 9p21 was associated with: 1) basal levels of IFN-I in plasma from 148 healthy male subjects; 2) induction of IFN-I by Toll-like receptor stimulants in peripheral blood mononuclear cells of 60 healthy volunteers assessed by enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21 CAD risk region in reporter assays.
|
23933542 |
2013 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
rs4977574
|
|
G |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
|
29263402 |
2017 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
rs4977574
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
rs11556924
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
rs11556924
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |