Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.100 | GeneticVariation | BEFREE | The KIF6 rs20455 polymorphism has been verified as an important genetic factor of coronary heart disease (CHD), but with controversial results. | 29304815 | 2018 |
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0.100 | GeneticVariation | BEFREE | The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis. | 28096762 | 2015 |
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0.100 | GeneticVariation | BEFREE | Trp 719Arg have an effect on development of Coronary Heart Disease but it is very useful for statin therapy. | 26443250 | 2015 |
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0.100 | GeneticVariation | BEFREE | The impact of rs20455 on CAD and non-fatal MI was evaluated in a dominant genetic model with stepwise multiple regression analysis. | 23001387 | 2012 |
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0.100 | GeneticVariation | BEFREE | Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect. | 23236363 | 2012 |
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0.100 | GeneticVariation | BEFREE | Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease. | 21435211 | 2011 |
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0.100 | GeneticVariation | BEFREE | Genotyping for Trp719Arg was done by an allele-specific real-time assay in 227 cases with confirmed CAD and 150 controls. | 21810021 | 2011 |
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0.100 | GeneticVariation | BEFREE | A single-nucleotide polymorphism Trp719Arg (rs20455T>C) in the kinesin-like protein 6 (KIF6), which is a protein involved in intracellular transport, has been shown to predict increased coronary artery disease (CAD) risk and event reduction during statin therapy. | 21810021 | 2011 |
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0.100 | GeneticVariation | BEFREE | The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. | 20933357 | 2010 |
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0.100 | GeneticVariation | BEFREE | Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. | 18222353 | 2008 |
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0.100 | GeneticVariation | BEFREE | We considered five variants that were associated with coronary heart disease in two studies and confirmed in the Atherosclerosis Risk in Communities study: rs20455 (KIF6), rs3900940 (MYH15), rs7439293 (PALLD), rs2298566 (SNX19), and rs1010 (VAMP8). | 18073581 | 2007 |