| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | GeneticVariation | BEFREE | Individuals with A/A or A/G genotypes of rs671 have a higher CAD risk, if they lack physical activity and take fried food regularly, than individuals with G/G genotypes. | 29960587 | 2018 |
||||
|
0.100 | GeneticVariation | BEFREE | In the subgroup analysis, the results revealed that rs671 were significantly associated with CAD (OR=1.24, 95%CI: 1.11-1.38, p<0.001) in non-alcoholic subjects. | 26995653 | 2016 |
||||
|
0.100 | GeneticVariation | BEFREE | Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease. | 27191745 | 2016 |
||||
|
0.100 | GeneticVariation | BEFREE | In this review, we update the current research on the association of the Glu504Lys</span> polymorphism with the susceptibility to CAD. | 25263942 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | The current meta-analysis provides strong evidence that ALDH2 Glu504Lys polymorphism may be associated with increased risk of CAD and MI in East Asians, especially among Chinese and Korean populations. | 24333098 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | After assigning the most common allele combination as a reference, allele combination A-C-C-T-C-A, which simultaneously possessed the risk alleles of rs2073478 and rs671 polymorphisms, was associated with a 1.80-fold greater risk of CAD. | 25047496 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls. | 24067347 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | In conclusion, this meta-analysis provides strong evidence that ALDH2 rs671 polymorphism may be associated with increased risks of CAD and MI. | 23685282 | 2013 |
||||
|
0.100 | GeneticVariation | BEFREE | ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression. | 23697560 | 2013 |
||||
|
0.100 | GeneticVariation | BEFREE | The rs671 polymorphism of ALDH2 is associated with CAD in Han Chinese, possibly by influencing HDL-C levels and endothelial ADMA levels. | 20417517 | 2010 |