Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2036914
rs2036914
F11
0.010 GeneticVariation BEFREE If validated, a F11 rs2036914/FGG rs2066865 risk prediction model should be tested as a stratification tool for prevention of thromboembolism in patients with acute lymphoblastic leukemia. 31715544

2019

dbSNP: rs2043211
rs2043211
0.010 GeneticVariation BEFREE Investigation of NF-κB-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia. 31428046

2019

dbSNP: rs2066865
rs2066865
FGG
0.010 GeneticVariation BEFREE If validated, a F11 rs2036914/FGG rs2066865 risk prediction model should be tested as a stratification tool for prevention of thromboembolism in patients with acute lymphoblastic leukemia. 31715544

2019

dbSNP: rs153109
rs153109
0.010 GeneticVariation BEFREE Association of IL-27 rs153109 and rs17855750 Polymorphisms with Risk and Response to Therapy in Acute Lymphoblastic Leukemia. 28828696

2018

dbSNP: rs17855750
rs17855750
0.010 GeneticVariation BEFREE Association of IL-27 rs153109 and rs17855750 Polymorphisms with Risk and Response to Therapy in Acute Lymphoblastic Leukemia. 28828696

2018

dbSNP: rs231775
rs231775
0.010 GeneticVariation BEFREE 153 donors and 153 children with acute lymphoblastic leukemia, acute myeloid leukemia or juvenile myelomonocytic leukemia who had undergone allogeneic HSCT were genotyped of CTLA-4 gene for rs3087243 (CT60G>A), rs231775 (+ 49 A>G) and rs4553808 using TaqMan real-time polymerase chain reaction. 29335768

2018

dbSNP: rs4553808
rs4553808
0.010 GeneticVariation BEFREE 153 donors and 153 children with acute lymphoblastic leukemia, acute myeloid leukemia or juvenile myelomonocytic leukemia who had undergone allogeneic HSCT were genotyped of CTLA-4 gene for rs3087243 (CT60G>A), rs231775 (+ 49 A>G) and rs4553808 using TaqMan real-time polymerase chain reaction. 29335768

2018

dbSNP: rs755622
rs755622
0.010 GeneticVariation BEFREE MIF-173G/C (rs755622) polymorphism as a risk factor for acute lymphoblastic leukemia development in children. 29996006

2018

dbSNP: rs766639320
rs766639320
0.010 GeneticVariation BEFREE 153 donors and 153 children with acute lymphoblastic leukemia, acute myeloid leukemia or juvenile myelomonocytic leukemia who had undergone allogeneic HSCT were genotyped of CTLA-4 gene for rs3087243 (CT60G>A), rs231775 (+ 49 A>G) and rs4553808 using TaqMan real-time polymerase chain reaction. 29335768

2018

dbSNP: rs10740055
rs10740055
0.010 GeneticVariation BEFREE Furthermore, the recessive models revealed that six SNPs were risk factors for acute lymphoblastic leukemia: rs10740055, rs7089424, rs10994982, rs7896246, rs10821938, and rs7923074. 28381164

2017

dbSNP: rs1339159756
rs1339159756
0.010 GeneticVariation BEFREE Integration of ruxolitinib into dose-intensified therapy targeted against a novel JAK2 F694L mutation in B-precursor acute lymphoblastic leukemia. 27860260

2017

dbSNP: rs1801265
rs1801265
0.010 GeneticVariation BEFREE The authors conclude that patients carrying the c.85T>C C allele have an increased risk of developing acute lymphoblastic leukemia and have inferior outcome, and that DPYD c.85T>C can be used as a guide for individualized treatment and the decision to utilize 5-fluorouracil in acute lymphoblastic leukemia patients. 28618970

2017

dbSNP: rs2274407
rs2274407
0.010 GeneticVariation BEFREE ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia. 28550450

2017

dbSNP: rs4880
rs4880
0.010 GeneticVariation BEFREE Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. 27019981

2017

dbSNP: rs6479778
rs6479778
0.010 GeneticVariation BEFREE Under the dominant model, SNPs rs7073837, rs10821936, rs7896246, and rs6479778 in males only showed striking association with acute lymphoblastic leukemia. 28381164

2017

dbSNP: rs1057519695
rs1057519695
0.010 GeneticVariation BEFREE Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia. 27145535

2016

dbSNP: rs1057519834
rs1057519834
0.010 GeneticVariation BEFREE Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia. 27145535

2016

dbSNP: rs11554290
rs11554290
0.010 GeneticVariation BEFREE Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia. 27145535

2016

dbSNP: rs116855232
rs116855232
0.010 GeneticVariation BEFREE In 270 children enrolled in clinical trials for acute lymphoblastic leukemia in Guatemala, Singapore and Japan, we identified four NUDT15 coding variants (p.Arg139Cys, p.Arg139His, p.Val18Ile and p.Val18_Val19insGlyVal) that resulted in 74.4-100% loss of nucleotide diphosphatase activity. 26878724

2016

dbSNP: rs147390019
rs147390019
0.010 GeneticVariation BEFREE In 270 children enrolled in clinical trials for acute lymphoblastic leukemia in Guatemala, Singapore and Japan, we identified four NUDT15 coding variants (p.Arg139Cys, p.Arg139His, p.Val18Ile and p.Val18_Val19insGlyVal) that resulted in 74.4-100% loss of nucleotide diphosphatase activity. 26878724

2016

dbSNP: rs186364861
rs186364861
0.010 GeneticVariation BEFREE In 270 children enrolled in clinical trials for acute lymphoblastic leukemia in Guatemala, Singapore and Japan, we identified four NUDT15 coding variants (p.Arg139Cys, p.Arg139His, p.Val18Ile and p.Val18_Val19insGlyVal) that resulted in 74.4-100% loss of nucleotide diphosphatase activity. 26878724

2016

dbSNP: rs56149945
rs56149945
0.010 GeneticVariation BEFREE We investigated whether an altered individual glucocorticoid sensitivity due to particular glucocorticoid receptor single-nucleotide polymorphisms (SNPs) (N363S, ER22/23EK, and Bcl-1) influences the susceptibility to steroid-related toxicities, prognostic factors, and survival rates in children with acute lymphoblastic leukemia. 27050122

2016

dbSNP: rs121913615
rs121913615
MPL
0.010 GeneticVariation BEFREE Retrospective molecular studies detected a MPL W515S homozygous mutation in both the initial and remission marrows for B-ALL, at 30-40% and 80% dosage effect, respectively. 25453399

2015

dbSNP: rs16754
rs16754
WT1
0.010 GeneticVariation BEFREE Wilms tumor gene single nucleotide polymorphism rs16754 predicts a favorable outcome in children with acute lymphoblastic leukemia. 26224397

2015

dbSNP: rs408626
rs408626
0.010 GeneticVariation BEFREE Influence of dihydrofolate reductase gene polymorphisms rs408626 (-317A>G) and rs442767 (-680C>A) on the outcome of methotrexate-based maintenance therapy in South Indian patients with acute lymphoblastic leukemia. 26335211

2015