rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals.
|
27122668 |
2016 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48).
|
23803045 |
2013 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis showed a significant association between KIF1B rs17401966 polymorphism and HCC.
|
24952890 |
2014 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs17401966 was genotyped using the TaqMan allelic discrimination assay in 414 intermediate or advanced hepatocellular carcinoma patients.
|
25153661 |
2014 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that KIF1B (rs17401966) polymorphism could decrease HCC risk in Chinese and in overall population, but not in non-Chinese.
|
29881295 |
2018 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC.
|
23634229 |
2013 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygous mutation of rs1081432 conferred a 2.68-fold risk of HCC (95% CI 1.35-5.34); however heterozygosity was not statistically significant. rs17401966 heterozygosity or homozygosity was not significantly associated with a increased risk of HCC.
|
25412941 |
2014 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC.
|
22712471 |
2012 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients.
|
28417047 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population.
|
23665287 |
2013 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19).
|
23024757 |
2012 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma.
|
28427234 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample.
|
29584564 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nevertheless, we also detected significant associations between rs259</span>6542G>A and HCV-induced HCC</span>.
|
30967497 |
2019 |