|
rs2844512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2844512 G > C variant in LINC01149 was identified to facilitate HBV spontaneous recovery (OR = 0.84, 95% CI = 0.77-0.92) but increase the risk of HCC (OR = 1.21, 95% CI = 1.11-1.32) in combined samples.
|
31754211 |
2020 |
|
rs34000982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that the rs34000982 polymorphism may contribute to HCC susceptibility, in full or at least partially through the effect on HMGB1 transcriptional activity by disturbing the binding of miR-636 with the 3'UTR of HMGB1.
|
31777261 |
2020 |
|
rs10036748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we found two risk alleles in TNIP1 for HBV-induced HCC in patients: the allele "G" of rs7708392 by genotype model ("G/C" vs. "C/C": OR 1.88, 95% CI 1.17-3, P = 0.009) and dominant model ("G/C-G/G" vs. "C/C": OR 1.69, 95% CI 1.08-2.65, P = 0.023), and the allele "C" of rs10036748 by genotype model ("C/T" vs. "T/T": OR 1.83, 95% CI 1.14-2.92, P = 0.012) and dominant model ("C/T-C/C" vs. "T/T": OR 1.65, 95% CI 1.05-2.59, P = 0.03).
|
30073579 |
2019 |
|
rs1010273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed that PRDM1 rs1010273 polymorphism was an independent factor associated with the overall survival of patients with HCC (odds ratio, 0.529; 95% confidence interval, 0.126-0.862; p = 0.002).
|
31376415 |
2019 |
|
rs10116253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, The peak of risk of HCC was observed with allele C of rs3804099 of TLR2 and C allele of rs10116253 TLR4 (<i>p</i> < 0.001).A strong association was found with allele T of rs1816702 of TLR2 and allele A of rs5030728 of TLR4 in non responder group in comparison to responders (<i>p</i> < 0.001).
|
31615295 |
2019 |
|
rs1014509103
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that six SNPs in ADAMTS4 were differential distribution between cases and controls via the primary screening analyses; however, only rs538321148 and rs1014509103 polymorphisms were further identified to modify the risk of HCC (odds ratio: 2.73 and 2.95; 95% confidence interval, 2.28-3.29 and 2.43-3.58; P-value, 5.73 × 10<sup>-27</sup> and 1.36 × 10<sup>-27</sup> , respectively).
|
31663692 |
2019 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs10514231
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bioinformatics analyses showed that allele C of ATG10 rs10514231 was significantly correlated with higher expression of ATG10 gene in both HCC tissues and normal liver tissues.
|
31340167 |
2019 |
|
rs1057868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphism <i>POR</i>-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], <i>P</i> = 0.003), but not significantly associated with RFS (CT/TT vs. CC, <i>P</i> = 0.378).
|
31031855 |
2019 |
|
rs10836347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Those who consumed alcohol who carried the rs10836347 CT genotype exhibited a risk factor for HCC.
|
31301090 |
2019 |
|
rs10932029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that <i>ICOS</i> rs10932029 T>C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups.
|
31235485 |
2019 |
|
rs1127717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, donor rs1801394 and rs1127717 polymorphism may serve as promising prognostic biomarkers for HCC recurrence in liver transplant recipients.
|
30529095 |
2019 |
|
rs11950384
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On univariate and multivariate analyses, elder age and having at least one copy of the mutant rs3210714 were associated with a significantly increased risk of HCC (P < 0.001 for both), whereas the presence of at least one copy of the mutant rs11950384 carried a significantly reduced risk of having HCC (P < 0.01).
|
30422339 |
2019 |
|
rs12252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymerase chain reaction (PCR) was employed to determine the gene polymorphism of IFITM3, and analyzed with the GraphPad Prism v 5.The patients with HCC had a significantly higher proportion of IFITM3 rs12252-CC as compared with the patients with chronic HBV infection or liver cirrhosis.
|
30633185 |
2019 |
|
rs12331678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional logistic regression analysis for the independent effect of one significant SNP suggested that rs12331678 or rs12503843 contributed an independent effect to the significant association with the risk of HCC, respectively.
|
28981558 |
2019 |
|
rs12427129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the effect of rs12427129 and rs3816153 on the risk of HCC could be modified by HBsAg status, while the rs12427129 CT/TT genotype could antagonize the detrimental effect of rs3816153 GT/TT genotype on HCC.
|
30556621 |
2019 |
|
rs12503843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional logistic regression analysis for the independent effect of one significant SNP suggested that rs12331678 or rs12503843 contributed an independent effect to the significant association with the risk of HCC, respectively.
|
28981558 |
2019 |
|
rs12947947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs12947947 and rs28363292 polymorphisms may jointly contribute to the risk of HCC.
|
30883040 |
2019 |
|
rs1329044438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case control study (1152 patients vs 1242 controls), we observed significant increase in HCC susceptibility in hepatitis B virus carriers associated with a nonsynonymous Thr83Ala variant of FOXA1 (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.11-1.48, for Ala83-containing genotype, after validation in an independent population with 933 patients vs 1030 controls), a tightly linked (CGC)5/6or7 repeat polymorphism at its promoter (OR 1.32; 95% CI 1.10-1.60, for (CGC)6or7-repeat-containing genotype), and their combined haplotype (OR 1.50; 95% CI 1.24-1.81, for (CGC)6or7-Ala83 haplotype).
|
31400761 |
2019 |
|
rs13347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the CD44 rs13347 site, mutations in the T allele might be a risk factor for HCC.
|
31301090 |
2019 |
|
rs139394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that <i>CBX4</i> rs2289728 and <i>CBX7</i> rs139394 are protective SNPs against HCC.
|
31211140 |
2019 |
|
rs17067724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found ATG5 rs17067724 (G vs A: OR = 0.80; 95% CI = 0.65-0.98; P = 0.031), ATG10 rs1864183 (G vs A: OR = 1.29; 95% CI = 1.07-1.57; P = 0.009), ATG10 rs10514231 (C vs T: OR = 1.41; 95% CI = 1.15-1.73; P = 0.001), ATG12 rs26537 (C vs T: OR = 1.16; 95% CI = 1.02-1.33; P = 0.030), and ATG16L1 rs4663402 (T vs A: OR = 1.28; 95% CI = 1.01-1.63; P = 0.044) were significantly associated with HCC risk.
|
31340167 |
2019 |
|
rs17375018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, IL-23R rs17375018 polymorphism might serve as a prognostic factor in patients with HCC after interventional therapy.
|
29864461 |
2019 |
|
rs1816702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, The peak of risk of HCC was observed with allele C of rs3804099 of TLR2 and C allele of rs10116253 TLR4 (<i>p</i> < 0.001).A strong association was found with allele T of rs1816702 of TLR2 and allele A of rs5030728 of TLR4 in non responder group in comparison to responders (<i>p</i> < 0.001).
|
31615295 |
2019 |
|
rs1864183
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found ATG5 rs17067724 (G vs A: OR = 0.80; 95% CI = 0.65-0.98; P = 0.031), ATG10 rs1864183 (G vs A: OR = 1.29; 95% CI = 1.07-1.57; P = 0.009), ATG10 rs10514231 (C vs T: OR = 1.41; 95% CI = 1.15-1.73; P = 0.001), ATG12 rs26537 (C vs T: OR = 1.16; 95% CI = 1.02-1.33; P = 0.030), and ATG16L1 rs4663402 (T vs A: OR = 1.28; 95% CI = 1.01-1.63; P = 0.044) were significantly associated with HCC risk.
|
31340167 |
2019 |