DisGeNET - a database of gene-disease associations

Pediatric Obesity, C2362324

Variant: rs6232 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs6232

PCSK1 ; LOC101929710

0.020

GeneticVariation

BEFREE

In addition to confirming rs6232 and rs6234 in <i>PCSK1</i> as polygenic risk variants for childhood obesity, we describe an association of rs725522 with insulin metabolism.

28271036

2017

dbSNP:

rs6232

PCSK1 ; LOC101929710

0.020

GeneticVariation

BEFREE

This meta-analysis confirmed the association of PCSK1 SNPs with obesity and provides the first evidence that the association between PCSK1 rs6232 and obesity is stronger for childhood obesity than for adult obesity.

25355447

2014